Proj
J-GLOBAL ID:200904085321934808  Research Project code:9800038203 Update date:Dec. 10, 2004

Selective protein degradation and its roles in cellular functions

選択的蛋白質分解による細胞機能の制御
Study period:1995 - 0
Organization (1):
Investigating Researcher (3):
Research overview:
The ubiquitin system takes part in biological regulation by provoking a selective degradation of key proteins for various cellular processes. Both ubiquitin-conjugating enzyme (E2) and ubiquitin ligase (E3) are known to exist as large families. An E2, alone or often along with its partner E3, recognizes specific or preferred subatrates and catalyzes conjugation of ubiquitin to them. The ubiquitinated proteins are led to rapid dagradation by proteasome. Our focus of research is the identification of ubiquitin pathways specific for degradation of key proteins for cell cycle regulation.
Keywords (8):
proteolysis ,  cultured cell ,  yeast ,  cell cycle ,  selectivity ,  ubiquitin ,  proteasomes ,  peptide synthetase
Project Organization (1):
  • (A158004000)
Research program: Ordinary Research
Ministry with control over the research :
Ministry of Education, Culture, Sports, Science and Technology
Research budget: 1997: \4,000,000

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