J-GLOBAL ID:200904087484260602  Research Project code:0350012616 Update date:Dec. 10, 2003

Development and clinical application of inhibitors, which work on Rho-kinase

Study period:2002 - 2006
Organization (1):
Investigating Researcher (1):
Research overview:
The arteriosclerotic disease (ischemic heart disease and cerebrovascular disorder are contained) occupies still large part of cause of death in our country. Now, we face an unprecedented situation with an aging society. Therefore, the effective prevention of these diseases and development of these therapies are very important from the social standpoint. We have found that Rho-kinase is involved in not only angina pectoris and pulmonary hypertension through abnormal contraction of vasucular smooth muscle but also arteriosclerosis formation and crisis of glomerulonephritis through migration of smooth muscle cell and macrophage. We recently found the possibility that Rho-kinase inhibitor shows the higher efficacy for pulmonary hypertension and coronary artery spasm and arteriosclerosis, etc. Our results concerning Rho-kinase are carefully watched around the world. However, the history of development of Rho-kinase inhibitor is short. We have not got the internal medicine of Rho-kinase inhibitor that can be administered to patients at present. Our research purpose is that the development and clinical application of inhibitor of Rho-kinase are efficiently carried out.
Keywords (3):
arteriosclerotic disease ,  Rho-kinase ,  inhibitor of Rho-kinase
Researcher representative of the project  (1):
  • KAIBUCHI Kozo (delegate)
Research program: Basic Research Promotion Service for Health and Medical Field
Ministry with control over the research :
Ministry of Health, Labour and Welfare

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