J-GLOBAL ID:200904087658447391  Research Project code:9800027148 Update date:Jan. 21, 1997

Regulation of cerebral and genital functions by prostaglandin D2 and its synthase, by means of volume transmission mode via the cerebrospinal fluid and the seminal fluid

プロスタグランジンD2およびその合成酵素の脳脊髄液及び精液を介する液性調節機構による脳機能及び生 殖機能調節
Study period:1998 - 2000
Research overview:
Prostaglandin (PG) D2 is an endogenous sleep-promoting substance. PGD synthase is a member of the lipocalin superfamily, a group of proteins comprising a variety of secretory proteins that bind and transport small lipophilic molecules such as retinol and retinoic acid. This enzyme is synthesized in the choroid plexus, leptomeninges, and oligodendrocytes of the central nervous system and is secreted into the cerebrospinal fluid as beta-trace protein, a major constituent of human cerebrospinal fluid. It is also produced in leydig cells of the testis and in epithelial cells of the prostate gland, and is secreted into the seminal plasma. Currently we investigate the physiological significance of the secretion of this enzyme and its product, PGD2, into the cerebrospinal fluid and the seminal plasma.
Keywords (6):
prostaglandin ,  sleep ,  protein ,  cerebrospinal ,  vitamin ,  semen
Researcher representative of the project  (1):
  • Yoshihiro Urade
Research program: Ordinary Research
Research budget: 1996: \10,000,000

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