Research Project code：9800027148
Update date：Jan. 21, 1997
Regulation of cerebral and genital functions by prostaglandin D2 and its synthase, by means of volume transmission mode via the cerebrospinal fluid and the seminal fluid
1998 - 2000
Prostaglandin (PG) D2 is an endogenous sleep-promoting substance. PGD synthase is a member of the lipocalin superfamily, a group of proteins comprising a variety of secretory proteins that bind and transport small lipophilic molecules such as retinol and retinoic acid. This enzyme is synthesized in the choroid plexus, leptomeninges, and oligodendrocytes of the central nervous system and is secreted into the cerebrospinal fluid as beta-trace protein, a major constituent of human cerebrospinal fluid. It is also produced in leydig cells of the testis and in epithelial cells of the prostate gland, and is secreted into the seminal plasma. Currently we investigate the physiological significance of the secretion of this enzyme and its product, PGD2, into the cerebrospinal fluid and the seminal plasma.
Researcher representative of the project (1)：
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