Proj

J-GLOBAL ID：200904088908968534 Research Project code：9800028182 Update date：Oct. 15, 2004

Study on tumor promotion in humans by TNF-alpha

腫瘍壊死因子TNF-αによるヒト発がんプロモーションの研究

Study period：1994 - 0
Organization (1)：
Investigating Researcher (1)：
Research overview：

Tumor necrosis factor alpha (TNF-alpha) stimulated cell transformation. The evidence suggests that TNF-alpha acts as a tumor promoter in human cancer development. Helicobacter pylori is classified into the definitive carcinogen for human stomach cancer. H. pylori infection is known to induce inflammation associated with induction of TNF-alpha. To investigate the significance of TNF-alpha in human carcinogenesis, we have studied carcinogenic activity of TNF-alpha inducing factors of H. pylori. We found TNF-alpha inducing protein (Tipalpha), a potent inducer of TNF-alpha, induced in vitro cell transformation, and study it's mechanisms of action.

Keywords (5)：

TNF-alpha , tumor promoter , tumor cells , Helicobacter pylori , stomach cancer

Project Organization (1)：

(E152000000)

Research program： Ordinary Research

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