J-GLOBAL ID:200904090891891766  Research Project code:9800005860 Update date:Feb. 17, 1998

Experimental study on role of mesocorticolimbic dopamine system for akinesia in Parkinson's disease

動物モデルによるパーキンソン病の病態研究 内側前脳束破壊による無動
Study period:1988 - 1996
Organization (1):
Investigating Researcher (2):
Research overview:
Akinesia is the cardinal symptom characterizing Parkinson's disease. We developed experimental animal model for analysis of the akinesia, especially hypokinesia (poverty of movement). The chronic akinetic state was elicited by bilateral electrolytic lesion of the medial forebrain bundle in cats. After neurobehavioral analysis, monoamine content of various brain sites was analyzed by HPLC. Dopamine was decreased significantly in the cortex, and prominently in the ventromedial part of the striatum and nucleus accumbens. It is conceivable that akinesta is mediated from the damage of the mesocorticolimbic dopamine system.
Keywords (7):
Parkinson ,  movement ,  paralytic ,  corpus ,  dopamine ,  cat(animal) ,  experimental
Research program: Ordinary Research
Research budget: 1996: \2,000,000

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