J-GLOBAL ID:200904091564123654  Research Project code:9800045853 Update date:Nov. 19, 2001

Interaction of H2 receptor antagonist-cimetidine with organophosphate

Study period:1997 - 2000
Organization (1):
Investigating Researcher (3):
Research overview:
Interaction between an H2 receptor antagonist, cimetidine and two organophosphate agents (fenthion and diazinon) was studied using rats. As the results, cimetidine showed enhancing effects on toxicity of fenthion but no effect on toxicity of diazinon. Currently, different modification of toxicity by cimetidine is studied by changes of choline esterase activity and isozymes.
Keywords (10):
cimetidine ,  fenthion ,  diazinon ,  drug interaction ,  toxicity ,  chemical modification ,  cholinesterase ,  activity ,  isozyme ,  variation
Research program: Ordinary Research

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