Research Project code：9911004429
Update date：Oct. 13, 2004
Study on genetic changes involved in incidence of esophageal cancers
1998 - 2003
Investigating Researcher (4)：
The factors related to outcome of esophagus cancers were searched on chromosome 13. Two commonly depleted regions were identified including BRCA2 gene and Rb gene, respectively which are representative suppressor genes on 13 chromosome. No variation was observed in BRCA2 gene. In Western blotting analysis for Rb gene, only 2 of 32 strains were detected to show abnormal expression. On the other hand, in analysis using polymorphic DNA markers, 84% of these strains were homozygous or hemizygous in these regions, presuming that neither BRCA2 nor Rb gene is the target gene for depletion of chromosome 13. The commonly deleted region related to lymph node metastasis was focused to about 2cM between D13S260 and D13S267. AS3 gene reported to be related to sensitivity to male hormone is located on this region. However, no tumor specific mutation of this gene was observed. We also analyzed a new candidate gene mapped in this region, LATS2. But this gene is also negative for esophageal cancer specific mutaion.
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