Research Project code：9910002241
Update date：Dec. 11, 2001
Effects of transcranial magnetic stimulation on dopamine metabolism and blood flow in the brain - for the treatment of Parkinson's disease.
経頭蓋磁気刺激が脳内 dopamine 代謝および脳血流に及ぼす影響-パーキンソン病の治療を目指して-
1998 - 2000
It has been reported that the transcranial magnetic stimulation is useful as a test method for various nerve systems including central and peripheral systems since it was reported by Baker in 1985. Its safety zones of magnetic stimulation was confirmed, and it was established as a test method for various diseases. Although it is only a method to stimulate the brain parenchyma with overcurrent non-invasively without pains, there is no case in which it was examined as a treatment method. Thus, the effects of transcranial magnetic stimulation on neural secretion and electrophysiological activity in basal ganglion are demonstrated in animals. Namely, changes of brain waves by chronic transcranial magnetic stimulation, changes of neurotransmitter concentrations, and changes of their receptors are examined. The changes of symptoms by transcranial magnetic stimulation are observed in model rats for Parkinson's disease. Transcranial magnetic stimulation in safety zones is conducted in healthy subjects and changes of blood flow and metabolism are examined by Xenon CT and MR spectroscopy. These three were the study purposes.
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