Susaki Etsuo A

スサキエツオ | Susaki Etsuo A

Affiliation and department：
Job title： Professor
Other affiliations (3)：

Juntendo University Nakatani Biomedical Spatialomics Hub, Graduate School of Medicine Head
RIKEN BDR Visiting Scientist
CUBICStars Co. Executive officer

Homepage URL (1)： http://www.dbsb.science

Research field (6)： Genetics , Cell biology , Molecular biology , Neuroanatomy and physiology , Neuroscience - general , Medical biochemistry

Research keywords (10)： Hydra biology & biotechnology , Aging , Cell Cycle , Three-dimensional histology , Systems biology , Bioimaging , Tissue clearing , 発生生物学 , 合成生物学 , Mouse genetics

Research theme for competitive and other funds (24)：

2023 - 2030 Interdisciplinary research on autophagy: From working principles to pathophysiology
2022 - 2028 Advanced Bioimaging Support
2022 - 2026 早期血管老化部位の網羅的全身探索と医学的介入効果の検証
2020 - 2024 title in Japanese
2022 - 2023 title in Japanese

2018 - 2023 Designing the mammalian biological oscillators

2019 - 2022 Development of whole-organ 3D staining method for the analysis of protein expression, modification, and activity

2017 - 2022 (Investigation of cellular diversity by a comprehensive 3D imaging method)

2018 - 2020 (Detecting Global States and Dynamics in Neural Circuit)

2018 - 2020 Development of basic technology for spatial genomics of in three-dimensional tissues

2020 - title in Japanese

2012 - 2019 (Development of tissue-clearing technology for high-throughput whole-body imaging)

2015 - 2019 (title in Japanese)

2015 - 2019 (Development of next-generation mouse genetics toward comprehensive identification of phenotype-related cells)

2016 - 2018 (Detecting Global Dynamics in Neural Circuit)

2014 - 2018 (Development of a 3D imaging method for temporal and spacial gene expression profiling and circuit analysis)

2017 - 2018 Identifying the brain's circuit for selective attentional centers

2014 - 2017 Developing basic technologies toward comprehensive circuit mapping of the primate brain

2013 - 2017 哺乳類概日振動体の構成的な理解

2014 - 2015 (Identification of brain state transitions by monitoring whole brain activities throughout 24 hours)

2011 - 2013 High-throughput Preparation of Gene-targeted Mice by Controlling the Ratio of Cell Types in Developmental Embryos

2010 - 2011 (Identification and analysis of sleep/wake-regulating neural circuits)

2009 - 2011 (Functional analysis of CDK inhibitors during development)

2009 - 2010 (Analysis of in vivo role of CDK inhibitors regulating developmental process and stem cell function)

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Papers (43)：

Hiroshi Nonaka, Seiji Sakamoto, Kazuki Shiraiwa, Mamoru Ishikawa, Tomonori Tamura, Kyohei Okuno, Takumi Kondo, Shigeki Kiyonaka, Etsuo A Susaki, Chika Shimizu, et al. Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 6. e2313887121
Akira Leon Yoshikawa, Takaki Omura, Atsushi Takahashi-Kanemitsu, Etsuo A. Susaki. Blueprints from plane to space: outlook of next-generation three-dimensional histopathology. Cancer Science. 2024. 115. 4. 1029-1038
Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, et al. The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells. Science signaling. 2023. 16. 794. eabp9020
Kohei Otomo, Takaki Omura, Yuki Nozawa, Yuri Saito, Etsuo A. Susaki. descSPIM: Affordable and Easy-to-Build Light-Sheet Microscopy for Tissue Clearing Technique Users. bioRxiv. 2023
Kazuhiro Kon, Koji L. Ode, Tomoyuki Mano, Hiroshi Fujishima, Daisuke Tone, Chika Shimizu, Shinnosuke Shiono, Saori Yada, Junko Yoshida Garçon, Mari Kaneko, et al. Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation. bioRxiv. 2023

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MISC (70)：

Atsushi Takahashi-Kanemitsu, Etsuo A. Susaki. A comprehensive whole cell analysis of organoids by Cell-omics technology. Jikken-Igaku (book title in Japanese). 2024. 42. 5. 176 (810)-182 (816)
Akira L. Yoshikawa, Kohei Otomo, Etsuo A. Susaki. Overview of light-sheet fluorescence microscopy and tissue clearing. OPTRONICS. 2024. 507. 3. 65-69
熊谷由美, 呉林なごみ, 長岡功, 洲崎悦生. 抗菌活性を持つ好中球由来エクトソームはマウス敗血症病態を改善する(Neutrophil-derived ectosomes with antibacterial potential ameliorate mouse sepsis). 日本細菌学雑誌. 2022. 77. 1. 101-101
Etsuo A. Susaki. Development and perspective of cell-omics technology. 生化学. 2022. 94. 1. 26-36
Etsuo A. Susaki. Basics and Applications of Tissue Clearing Technology. TCI mail. 2022. 189. 189. 10-17

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Patents (6)：

BIOLOGICAL TISSUE;STAINING REAGENT;BIOLOGICAL TISSUE;STAINING KIT AND;BIOLOGICAL TISSUE;STAINING METHOD
CUBIC-HV(TM)
Composition for preparing biomaterial with excellent light-transmitting property, and use thereof
光透過性に優れた生物材料を調製するための組成物およびその利用(国内出願)
(A screening method for anti-obesity drugs)

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Books (8)：

Light-sheet imaging guide
Yodosha 2023 ISBN:9784758122689
Handbook of Tissue Optical Clearing - New Prospects in Optical Imaging. Editors: Dan Zhu, Elina A. Genina, Valery V. Tuchin
CRC Press 2022 ISBN:9781000466300
Handbook for Medical Engineering
NTS inc. 2022 ISBN:9784860437350
Cutting-edge Analytical Techniques, 2nd Edition
NTS inc. 2022 ISBN:9784860437374
Bio-innovation - Novel Developments by New Biotechnologies (Japanese)
CMC Publishing 2019 ISBN:9784781314112

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Lectures and oral presentations (149)：

Cell-omics technology: dive into the three-dimensional cell cloud
(Seminar at LENS, Italy 2024)
CUBIC-HistoVIsion2.0: expanded volumetric staining through phase separation and compound optimization
(FOM2024 2024)
(title in Japanese)
(Seminar at Graduate School of Medicine, Kyushu University 2024)
(title in Japanese)
(The 5th Research Conference of Research Society for Cancer 3D Culture 2024)
(title in Japanese)
(TMiMS Seminar 2024)

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Professional career (1)：

M.D., Ph.D (Kyushu University)

Work history (14)：

2021/04 - 現在 Department of Biochemistry and Systems Biomedicine, Juntendo University Graduate School of Medicine Professor
2024/04 - 2029/03 Juntendo University Nakatani Biomedical Spatialomics Hub, Graduate School of Medicine Head
2019/11 - 2021/03 Graudate School of Medicine, The University of Tokyo Department of Systems Pharmacology Associate professor
2019/09 - 2020/03 Waseda University Faculty of Science and Engineering
2017/01 - 2019/10 UTokyo Graduate School of Medicine Department of Systems Pharmacology Lecturer/Senior research associate

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Awards (7)：

2021/09 - U.S. National Academy of Medicine International Catalyst Award of Healthy Longevity Global Competition 2021 "Clarifying the origins and very early processes of aging in tissue"
2019/03 - JST さきがけ「1細胞解析」研究領域特別賞
2017/04 - The Minister of Education, Culture, Sports, Science and Technology The Young Scientists’ Prize of The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology "Development of novel technologies toward the organism-level systems biology"
2017/03 - 国立研究開発法人日本医療研究開発機構/ニューヨーク科学アカデミー Interstellar Initiative 選抜参加
2015/03 - The 88th Annual Meeting of the Japanese Pharmacological Society Selected Presentation Award

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Association Membership(s) (3)：

The Japanese Biochemical Society , Japanese Society of Digital Pathology , 日本分子生物学会

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