Rchr
J-GLOBAL ID：201001019721259872
Update date: Mar. 18, 2024
Mouri Akihiro
モウリ アキヒロ | Mouri Akihiro
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.fujita-hu.ac.jp/~regulatory/
Research field (4)：
Pharmacology
, Laboratory animal science
, Neuroscience - general
, Pharmacology
Research keywords (7)：
Biomarker
, Behavioral pharmacology
, Drug dependence
, Alzheimer`s disease
, Autism
, Schizophrenia
, Depression
Research theme for competitive and other funds (13)：
- 2022 - 2025 The influence of disruption of myelin-neuron network on major depressive disorder
- 2020 - 2023 統合失調症の発症・病態仮説に共通するトリプトファン代謝に注目した予防・治療戦略
- 2017 - 2022 Development of the next-generation diagnosis method for depression by using byomakers based on pathophysiological mechanism
- 2018 - 2021 Relationship between changes in amino acid metabolism during pregnancy and postpartum depression.
- 2017 - 2020 Development of novel therapeutic agents for schizophrenia based on kynurenine hypothesis
- 2016 - 2019 Association between brain malformations of neurodevelopmental psychiatric disorders and PGE2-EP1 signaling
- 2016 - 2019 Development of functional molecule-targeted diagnostic and therapeutic agents for attention deficit hyperactivity disorder
- 2014 - 2017 Investigation in mechanism and therapeutic strategy into vulnerability to mood disorder after exposure to stress in the stage of neuro-development of mice
- 2013 - 2017 The role of synaptic vesicle protein 2A (SV2A) in the pathophysiology and treatment of Autism spectrum disorders
- 2014 - 2016 Involvment of ubiquitin-proteasome system in the pathophsiology of depression
- 2012 - 2015 Involvement of prostaglandin E2 in pathogenesis of schizophrenia
- 2011 - 2012 The development of novel schizophrenia animal models based on the clinical findings
- 2008 - 2010 Influences of genetic and environmental factors on schizophrenia
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Papers (135)：
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Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Tomoki Kawai, Moeka Tanabe, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri. Chronic social defeat stress induces the down-regulation of the Nedd4L-GLT-1 ubiquitination pathway in the prefrontal cortex of mice. Journal of Neurochemistry. 2024
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Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, et al. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2024. 291. 5. 945-964
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Mariko Nakamura, Akira Yoshimi, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Tomoya Miyauchi, Kunihiro Iwamoto, Mikiko Ito, Aiji Sato-Boku, Akihiro Mouri, et al. Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein. Pain. 2024
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Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, et al. High salt induces cognitive impairment via the interaction of angiotensin II-AT1 and prostaglandin E2-EP1 systems. British journal of pharmacology. 2023. 180. 18. 2393-2411
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Akihiro Mouri, Masaya Hasegawa, Kazuo Kunisawa, Kuniaki Saito, Toshitaka Nabeshima. [Diagnoses and new therapeutic strategy focused on physiological alteration of tryptophan metabolism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023. 158. 3. 233-237
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MISC (289)：
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國澤 和生, 毛利 彰宏. 心理的ストレスと腸内細菌叢 : 脳内炎症の観点から. Depression strategy : うつ病治療の新たなストラテジー. 2024. 14. 1. 10-12
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毛利 彰宏, 新島 萌, 國澤 和生, 高野 一輝, 山田 雅之, 勅使河原 知明, 藤垣 英嗣, 山本 康子, 長谷川 眞也, 倉橋 仁美, et al. QPRTの欠損によるキノリン酸の増加はドパミン作動性神経系における酸化ストレスを介した運動・認知機能障害を惹起する. 日本神経精神薬理学会年会プログラム・抄録集. 2023. 53回. 154-154
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國澤 和生, 小菅 愛加, 飯田 翼, 齋藤 邦明, 鍋島 俊隆, 毛利 彰宏. 社会的敗北ストレス負荷によるうつ様行動はユビキチン化酵素Nedd4L発現低下によるグルタミン酸神経機能低下を介している. 日本神経精神薬理学会年会プログラム・抄録集. 2023. 53回. 176-176
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毛利 彰宏, 新島 萌, 國澤 和生, 高野 一輝, 山田 雅之, 窪田 悠力, 平川 茉実, 森 優子, 山本 康子, 藤垣 英嗣, et al. QPRTの欠損はキノリン酸によるドパミン作動性神経系における酸化ストレスを増強し,運動・認知機能障害を惹起する. 日本生理学雑誌. 2023. 85. 3. 18-18
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國澤 和生, 田辺 萌夏, 齋藤 いまり, 小菅 愛加, 河合 智貴, 窪田 悠力, 齋藤 邦明, 鍋島 俊隆, 毛利 彰宏. レパミピドは大腸杯細胞の増殖を促し,社会的隔離ストレスによる行動異常を緩解する. 日本生理学雑誌. 2023. 85. 3. 18-19
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Patents (4)：
Books (1)：
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Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid β and impairment of learning and memory
[s.n.] 2007
Education (3)：
- 2003 - 2007 Graduate School of Medicine, Nagoya University Docter course
- 2001 - 2003 Graduate School of Pharmacy, Gifu pharmaceutical University, Faculty of Pharmacy Master course
- 1997 - 2001 Gifu pharmaceutical university Faculty of Pharmacy
Professional career (1)：
Work history (7)：
- 2022/04 - 現在 Fujita Health University Department of Regulatory Science for Evaluation and Development of Pharmaceuticals and Devices, School of Health Sciences Professor
- 2017/04 - 2022/03 Fujita Health University Department of Regulatory Science for Evaluation and Development of Pharmaceuticals and Devices, School of Health Sciences Faculty of Medical Technology Associate professor
- 2016/04 - 2017/04 Graduate School of Health Sciences, Fujita Health University Advanced Diagnostic System Research Laboratory Senior assistant professor
- 2012/04 - 2016/03 Meijo University Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy Assistant prosfessor
- 2010/05 - 2012/03 Nagoya University Graduate School of Medicine Department of Neuropsychopharmacology and Hospital Pharmacy Specially Appointed Assistant Professor
- 2007/10 - 2010/03 Ministry of Health, Labour and Welfare Regulatory science for drug development Research Resident
- 2007/05 - 2007/09 Graduate School of Pharmaceutical Sciences, Meijo University Department of Chemical Pharmacology Postdoctral fellow
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Awards (7)：
- 2017/10 - 藤田医科大学 産学連携推進センター 産学連携推進センター長賞
- 2017 - 日本神経精神薬理学会 JSNP Excellent Presentation Award for AsCNP The ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients
- 2014/01 - 愛知県若手研究者イノベーション創出奨励事業 第8回「わかしゃち奨励賞」最優秀賞 タンパク分解シグナルを標的としたうつ病診断法の開発
- 2011/10 - 内藤記念科学振興財団 第32回内藤コンファレンス優秀発表賞受賞
- 2011/08 - 2nd Congress of Asian College of Neuropsychopharmacology Fellowship Award.
- 2010 - ニコチン・薬物依存研究フォーラム 2010年度米国薬物依存問題学会(CPDD)年会 参加奨励賞受賞
- 2007/07 - 日本生物学的精神医学会 第29回日本生物学的精神医学会・第37回日本神経精神薬理学会 合同年会 優秀演題賞 アルツハイマー病モデルマウスの加齢による認知障害に対するアデノ随伴ウイルスベクター経口ワクチンの効果
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