Rchr
J-GLOBAL ID:201001049040159728   Update date: Jul. 31, 2020

Minamishima Yoji Andrew

Minamishima Yoji Andrew
Affiliation and department:
Homepage URL  (2): http://biochemistry.med.gunma-u.ac.jphttp://biochemistry.med.gunma-u.ac.jp/en/
Research field  (4): Pathobiochemistry ,  Medical biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (6): Cell cycle ,  Hydrogen sulfide ,  Cancer biology ,  Metabolism ,  Hypoxia ,  Cellular senescence
Research theme for competitive and other funds  (11):
  • 2014 - 2019 Investigation of hypoxia adaptation and metabolic regulation in the cancer- and senescence-resistant rodent, the naked mole rat.
  • 2014 - 2017 Identification of the specific metabolic system for cellular senescence and tumorigenesis
  • 2013 - 2016 Maintenance of CML stem cells through regulation of C/EBPbeta transcription factor
  • 2012 - 2015 Elucidation of activating Cori cycle caused by inhibition of PHD2 in liver
  • 2012 - 2015 Hypoxic response as a new treatment of Post cardiac arrest syndrome
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Papers (31):
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MISC (17):
  • Yoji Andrew Minamishima. Hypoxic response as a therapeutic target of human diseases. Folia Pharmacologica Japonica. 2020. 155. 1. 40-45
  • Oxygen-sensing prolyl hydroxylase PHD as a therapeutic target of metformin-associated lactic acidosis (MALA). 2019. 49. 3. 218-225
  • 小西 昭充, 南嶋 洋司. BRCA1複合体による機能不全テロメアにおける細胞周期特異的なDNA損傷修復の制御機構(BRCA1 complex regulates cell cycle-dependent DNA damage repair at telomeres to maintain chromosome integrity). 日本癌学会総会記事. 2019. 78回. P-3241
  • Minamishima Yoji Andrew. Targeting hypoxic response machinery for the treatment of critical diseases ~ Clinical application of PHD inhibitors ~. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 0. 2-S13-3
  • 松永哲郎, 守田匡伸, 南嶋洋司, 西村明, 井田智章, 藤井重元, 本橋ほづみ, 赤池孝章. 活性パースルフィドによるミトコンドリア膜電位形成機構の解明. 日本酸化ストレス学会学術集会プログラム・抄録集. 2018. 71st. 172
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Patents (1):
  • Drug For Preventing Or Treating Lactic Acidosis
Education (1):
  • 1998 - 2002 Kyushu University Graduate School of Medical Science
Professional career (2):
  • M.D. (Kyushu University)
  • Ph.D. (Kyushu University)
Work history (11):
  • 2018/12 - 現在 Professor, Department of Biochemistry, Gunma University Graduate School of Medicine
  • 2016/04 - 2018/11 Project Associate Professor, Division of Cell Biology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
  • 2010/09 - 2016/03 Assistant Professor, Department of Biochemistry, Keio University School of Medicine
  • 2010/09 - 2016/03 Group Leader, ERATO, Japan Science and Technology Agency (JST)
  • 2004/09 - 2010/08 Research Fellow, Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School
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Committee career (1):
  • 2013/10 - 現在 Cancer and Metabolism Meeting Executive committee
Awards (2):
  • 2017/03 - The Japanese Pharmacological Society Young Investigator Outstanding Oral Presentation Award, The 90t Annual Meeting of the Japanese Pharmacological Society Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis
  • 2009/08 - Dana-Farber Cancer Institute 5th Annual Postdoc and Grad Student Retreat Best Poster Presentation Award "Detrimental effect of chronic HIF activation in vivo"
Association Membership(s) (9):
THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE JAPANESE CANCER ASSOCIATION ,  The Japanese Biochemical Society ,  American Association for Cancer Research ,  JAPAN SURGICAL ASSOCIATION ,  THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY ,  JAPAN SURGICAL SOCIETY ,  The Molecular Biology Society of Japan
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