Rchr
J-GLOBAL ID：201001053531378550   Update date: Apr. 08, 2024

Ishigaki Shinsuke

イシガキ シンスケ | Ishigaki Shinsuke
Affiliation and department：
Shiga University of Medical Science Molecular Neuroscience Research Center

About Shiga University of Medical Science Molecular Neuroscience Research Center


Job title： Professor
Homepage URL  (2)： https://mnrc2.jp/ ,  https://mnrc2.jp/en/
Research field  (4)： Neuropathology ,  Animals: biochemistry, physiology, behavioral science ,  Neuroscience - general ,  Neurology
Research keywords  (7)： FTLD ,  ALS ,  FUS ,  tau ,  SFPQ ,  TDP-43 ,  ER stress
Research theme for competitive and other funds  (12)：
  • 2021 - 2025 天然変性領域 (IDR) 形成を支えるスプライシング機構から俯瞰する相分離現象
  • 2021 - 2025 FTLDスペクトラムにおける核内RNP複合体の機能変化に基づく核酸医療の開発
  • 2019 - 2024 ゴルジ体ストレスシグナルに着目した新たな老年病発症メカニズムの解析
  • 2021 - 2024 Development of oligonucleotide therapeutics targeting liquid-liquid phase separation for FTLD
  • 2021 - 2024 Development of novel translational test batteries using FTLD model marmosets
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Papers (83)：
  • Asraa Faris Aldoghachi, Daijiro Yanagisawa, Aslina Pahrudin Arrozi, Zulzikry Hafiz Abu Bakar, Hiroyasu Taguchi, Shinsuke Ishigaki, Katsutaro Morino, Ikuo Tooyama. Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochemical and Biophysical Research Communications. 2024. 694
  • Riki Koike, Yoshiyuki Soeda, Atsushi Kasai, Yusuke Fujioka, Shinsuke Ishigaki, Akihiro Yamanaka, Yuta Takaichi, James K Chambers, Kazuyuki Uchida, Hirohisa Watanabe, et al. Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex. Brain communications. 2024. 6. 1. fcad359
  • Akihiko Takashima, Riki Koike, Yoshiyuki Soeda, Yusuke Fujioka, Shinsuke Ishigaki, Hirohisa Watanabe. Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles. Alzheimer's & Dementia. 2023. 19. S22
  • Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Mana Inoue, Seiichi Nagano, Tsuyoshi Fujihara, Seiji Matsuda, Shinsuke Ishigaki, et al. Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice. Molecular therapy. Nucleic acids. 2023. 31. 353-366
  • Yuichi Riku, Mari Yoshida, Yasushi Iwasaki, Gen Sobue, Masahisa Katsuno, Shinsuke Ishigaki. TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?. International journal of molecular sciences. 2022. 23. 24
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MISC (29)：
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Patents (1)：
Books (1)：
  • Phase Separation in Living Cells
    Springer, Singapore. 2023 ISBN:9789819948857
Education (2)：
  • 1998 - 2002 Nagoya University Graduate School of Medicine
  • 1990 - 1996 Nagoya University School of Medicine
Professional career (1)：
  • 博士(医学) (名古屋大学)
Work history (6)：
  • 2022/05 - Shiga University of Medical Science Molecular Neuroscience Research Center Professor
  • 2010/04 - 2022/04 名古屋大学 医学(系)研究科(研究院) その他
  • 2005/09 - 2010/03 University of Massachusetts Medical School Postdoctral fellow
  • 2004/04 - 2005/08 名古屋大学医学部附属病院 医員
  • 2002/10 - 2004/03 東京都臨床医学総合研究所 特別研究員
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Association Membership(s) (4)：
society for neuroscinece ,  JAPAN SOCIETY FOR DEMENTIA RESEARCH ,  THE JAPAN NEUROSCIENCE SOCIETY ,  JAPANESE SOCIETY OF NEUROLOGY
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