Rchr
J-GLOBAL ID：201001053900160599   Update date: Jan. 31, 2024

Shimada Akira

シマダ アキラ | Shimada Akira
Affiliation and department：
Jichi Medical University Department of Pediatrics

About Jichi Medical University Department of Pediatrics


Job title： Professor
Research field  (1)： Fetal medicine/Pediatrics
Research keywords  (5)： 感染免疫学 ,  血液腫瘍学 ,  小児科 ,  hematology/oncology. immunology/infectious disease ,  Pediatrics
Research theme for competitive and other funds  (6)：
  • 2020 - 2023 Molecular analysis of pediatric acute megakaryoblastic leukemia without Down syndrome
  • 2015 - 2019 Molecular analysis of pediatric MDS/AML
  • 2014 - 2015 Establishment of new system for genomic analysis for AML using by desk-top next generation sequencer
  • 2012 - 2015 Development of novel molecular targeted therapy for juvenile myelomonocytic leukemia
  • 2011 - 2013 Analysis of the resistant mechanism of AML stem cells for tyrosine kinase inhibitor in bone marrow microenvironment
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Papers (168)：
  • Takahiro Aoki, Norio Shiba, Shinichi Tsujimoto, Genki Yamato, Yusuke Hara, Shota Kato, Kenichi Yoshida, Seishi Ogawa, Yasuhide Hayashi, Shotaro Iwamoto, et al. High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor. Pediatric blood & cancer. 2023. e30803
  • Yusuke Hara, Norio Shiba, Kenichi Yoshida, Genki Yamato, Taeko Kaburagi, Yuichi Shiraishi, Kentaro Ohki, Yusuke Shiozawa, Machiko Kawamura, Hirohide Kawasaki, et al. TP53 and RB1 alterations characterize poor prognostic subgroups in pediatric acute myeloid leukemia. Genes, chromosomes & cancer. 2023. 62. 7. 412-422
  • Genki Yamato, Tomoko Kawai, Norio Shiba, Junji Ikeda, Yusuke Hara, Kentaro Ohki, Shin-Ichi Tsujimoto, Taeko Kaburagi, Kenichi Yoshida, Yuichi Shiraishi, et al. Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia. Blood advances. 2022. 6. 11. 3207-3219
  • Takashi Taga, Shiro Tanaka, Daisuke Hasegawa, Kiminori Terui, Tsutomu Toki, Shotaro Iwamoto, Hidefumi Hiramatsu, Takako Miyamura, Yoshiko Hashii, Hiroshi Moritake, et al. Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome (Leukemia, (2021), 35, 9, (2508-2516), 10.1038/s41375-021-01157-w). Leukemia. 2021. 35. 12. 3622-3624
  • 大和 玄季, 河合 智子, 柴 徳生, 原 勇介, 大木 健太郎, 鏑木 多映子, 吉田 健一, 白石 友一, 宮野 悟, 清河 信敬, et al. Genome-wide DNA methylation analysis in pediatric AML: The JCCG-JPLSG AML-05 study(和訳中). 日本血液学会学術集会. 2021. 83回. OS2-4
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MISC (94)：
  • Genki Yamato, Tomoko Kawai, Norio Shiba, Yusuke Hara, Kentaro Ohki, Taeko Kaburagi, Etsuko Ishikita, Hirohide Kawasaki, Kenichi Yoshida, Yuichi Shiraishi, et al. Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study. BLOOD. 2022. 140. 9134-9135
  • 坪井伸成, 黒住和彦, 中野嘉子, 鷲尾佳奈, 嶋田明, 吉田朗彦, 河野隆志, 市村幸一, 柳井広之, 伊達勲. ARHGEF2-NTRK1融合遺伝子を有する高悪性度グリア神経細胞腫瘍の1例. Brain Tumor Pathology (Web). 2020. 37. Supplement
  • Takahiro Aoki, Hiroyuki Takahashi, Shiro Tanaka, Norio Shiba, Daiichiro Hasegawa, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, et al. Predisposition to Prolonged Neutropenia After Chemotherapy was Associated With Better Prognosis in Patients With Acute Myeloid Leukemia. PEDIATRIC BLOOD & CANCER. 2019. 66. S21-S21
  • Shimada Akira, Hasegawa Daiichiro, Imamura Toshihiko, Kaneda Makoto, Yagi Keiko, Takahashi Yoshihiro, Usami Ikuya, Suenobu Souichi, Nishimura Shinichiro, Hashii Keiko, et al. JACLS ALL02研究におけるAcute Mixed Leukemiaの遺伝子変異(Genetic Alterations in Acute Mixed Leukemia, Result of JACLS-ALL02 study). 日本小児血液・がん学会雑誌. 2019. 56. 4. 194-194
  • Hara Yusuke, Taki Tomohiko, Yamato Genki, Yoshida Kenichi, Shiba Norio, Kaburagi Taeko, Shiraishi Yuichi, Ohki Kentaro, Kawamura Machiko, Sotomatsu Manabu, et al. TP53遺伝子異常を伴う小児急性骨髄性白血病の臨床像と分子生物学異常の解析(Clinical and molecular characterization of pediatric acute myeloid leukemia with TP53 alterations). 日本小児血液・がん学会雑誌. 2019. 56. 4. 192-192
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Lectures and oral presentations  (20)：
  • Panel-based NGS Identifies Prognostic and Actionable Genes in Childhood Acute Lymphoblastic Leukemia and Suits for Clinical Sequence.
    (109th Annual Meeting of American Association of Cancer Research 2018)
  • Aberrant Methylation of Tumor Suppressor Genes in Pediatric Myelodysplastic Syndrome / Acute Myeloid Leukemia.
    (109th Annual Meeting of American Association of Cancer Research 2018)
  • The challenge of risk-reclassification of Pediatric AML with FLT3 wild type - JPLSG AML05 study,
    (Annual Meeting of International BFM study group 2016)
  • Poor prognosis with different induction rate was observed in children with acute myeloid leukemia and FLT3-ITD according to the ITD/WT allelic ratio: a result from the Japanese Pediatric Leukemia/Lymphoma Study Group
    (米国血液学会 2013)
  • 末梢血中WT1mRNA定量とFCM-MRDが再発の早期発見に有効であったAML-M7の 一例
    (日本小児血液がん学会 2013)
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Education (4)：
  • - 1999 Tottori University
  • - 1999 Tottori University Graduate School, Division of Medicine
  • - 1992 Tottori University Faculty of Medicine
  • - 1992 Tottori University Faculty of Medicine
Professional career (1)：
  • MD., PhD (Tottori University)
Work history (7)：
  • 2021/06 - 現在 Jichi Medical University Department of Pediatrics Professor
  • 2016/07 - 2021/05 Okayama University Department of Pediatric Hematology?Oncology Associate Professor
  • 2012/04 - 2016/06 Okayama University Department of Pediatrics Assistant Professor
  • 2009/10 - 2012/03 Nagoya University Department of Pediatrics
  • 2007/08 - 2009/08 St.Jude Children's Research Hospital Department of Pharmacology Post.Doc fellow
Show all
Awards (1)：
  • 2011 - クレディセゾン賞
Association Membership(s) (11)：
日本臨床腫瘍学会 ,  日本家族性腫瘍学会 ,  日本人類遺伝学会 ,  日本造血細胞移植学会 ,  日本小児血液がん学会 ,  アメリカ癌学会 ,  日本血液学会 ,  米国血液学会 ,  日本小児科学会 ,  American Association of Cancer Research ,  Japan Pediatric Society
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