Research theme for competitive and other funds (14)：
2021 - 2026 Development of treatment and animal model for SFTS based on genome-wide screening.
2015 - 2016 Development of a method for real-time measuring ion concentrations within membrane contact sites
2014 - 2015 Identification of proteins involved in membrane contact sites between peroxisome and ER
2013 - 2014 Visualizing membrane contact site between the ER and Golgi to analyze the functional kinetics
2011 - 2014 Study of pH homeostasis in acidic organelles
2009 - 2014 Molecular mechanisms and functions of structural changes of protein GPI-anchors
2011 - 2012 Study of Golgi pH sensor and the mechanism for the localization
2007 - 2008 Stage specific modifications of GPI anchor in Trypanosoma brucei
2002 - 2006 GPIアンカー合成の調節機構と合成不全症
2004 - 2005 The regulation of functions and expressions of proteins by glycosylphosphatidylinositol-anchor
2004 - 2005 GPIアンカー型蛋白質の輸送機構の解明:ラフトヘのアプローチとして
2001 - 2002 Biosynthesis pathway of GPI anchored proteins.
Glycosyl phosphatidyl Inositol(GPI)アンカーの生合成経路の解析
Analysisof biosynthesis of GPI anchor
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Papers (105)：
Yu-Shin Sou, Junji Yamaguchi, Hiroshi Kameda, Keisuke Masuda, Yusuke Maeda, Yasuo Uchiyama, Masato Koike. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters. 2022. 596. 22. 2873-2888
Masako Kohyama, Tatsuya Suzuki, Wataru Nakai, Chikako Ono, Sumiko Matsuoka, Koichi Iwatani, Yafei Liu, Yusuke Sakai, Atsushi Nakagawa, Keisuke Tomii, et al. SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses. International immunology. 2022. 35. 1. 43-52
Tetsuya Hirata, Atsushi Kobayashi, Tamio Furuse, Ikuko Yamada, Masaru Tamura, Hiroyuki Tomita, Yuko Tokoro, Akinori Ninomiya, Yoshitaka Fujihara, Masahito Ikawa, et al. Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. The Journal of biological chemistry. 2022. 298. 3. 101720-101720
Yuko Tashima, Tetsuya Hirata, Yusuke Maeda, Yoshiko Murakami, Taroh Kinoshita. Differential use of p24 family members as cargo receptors for the transport of glycosylphosphatidylinositol-anchored proteins and Wnt1. Journal of biochemistry. 2022. 171. 1. 75-83
Junki Hirano, Sachiyo Yoshio, Yusuke Sakai, Li Songling, Tatsuya Suzuki, Yumi Itoh, He Zhang, David Virya Chen, Saori Haga, Hiroko Oomori, et al. Hepatitis C virus modulates signal peptide peptidase to alter host protein processing. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 22
前田 裕輔, 井出 徹, 小池 正人, 内山 安男, 木下 タロウ. 糖鎖による生体膜近傍の細胞機能制御機構 Golgi装置の酸性化は新規アニオンチャンネルGPHRにより制御されグリコシル化において重要である(Acidification of the Golgi apparatus is regulated by GPHR, a novel anion channel, and critical for glycosylation). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2008. 81回・31回. 2S12-4
Host factors involved in chikungunya virus replication
(Joint International Tropical Medicine Meeting "Tropical Disease Control amid the COVID-19 Pandemic" 2020)
Roles of G3BP and stress granules on the replication of chikungunya virus
(第67回日本ウイルス学会 2019)
Proteomics analysis using in vivo proximity labeling uncovered host factors involved in chikungunya virus genome replication
(第66回日本ウイルス学会 2018)
