Ohnishi Kazuo

オオニシカズオ | Ohnishi Kazuo

Affiliation and department：
Job title： Principal Senior Scientist
Other affiliations (1)：

National Institute of Infectious Diseases Visiting Scientist

Homepage URL (1)： http://www.nih.go.jp/niid/immunology/Ohnishi-J.html

Research field (8)： Molecular biology , Medical biochemistry , Systems genomics , Structural biochemistry , Cell biology , Immunology , Virology , Bacteriology

Research keywords (9)： Exosome , Mesenchymal stem cells , Vaccine development , Antibody repertoire network , Antibody drugs , Antibody diagnostic kits , immune response to virus/bacteria , Molecular structure of the antibody molecule , Antibody-producing B cells

Research theme for competitive and other funds (13)：

2017 - 2020 Exploring the mechanism of SFTS pathogenesis by antibody gene repertoire analysis
2015 - 2017 Explicit representation of holistic antibody repertoire by exhaustive RNA sequencing and the antibody expression by reverse genetics
2006 - 2015 Research on the technological basis for virus detection in vitro diagnostics
2005 - 2015 Molecular Mechanisms of B Cell Immunological Memory
2003 - 2015 Immune response to viruses and bacteria

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Papers (21)：

Masashi Shingai, Sayaka Iida, Naoko Kawai, Mamiko Kawahara, Toshiki Sekiya, Marumi Ohno, Naoki Nomura, Chimuka Handabile, Tomomi Kawakita, Ryosuke Omori, et al. Extraction of the CDRH3 sequence of the mouse antibody repertoire selected upon influenza virus infection by subtraction of the background antibody repertoire. Journal of Virology. 2024
Takeyuki Shimizu, Lin Sun, Kazuo Ohnishi. Influence of pre-B cell receptor deficiency on the immunoglobulin repertoires in peripheral blood B cells before and after immunization. Molecular Immunology. 2024. 166. 87-100
OHNISHI Kazuo. Artificial immunoglobulin light chain with potential to associate with a wide variety of immunoglobulin heavy chains. Biochem. Biophys. Res. Commun. 2019. 515. 481-486
Sun, L, Kono, N, Toh, H, Xue, H, Sano, K, Suzuki, T, Ainai, A, Orba, Y, Yamagishi, J, Hasegawa, H, et al. Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing. J. Vis. Exp. 2019. 145. e58804
Shuetsu Fukushi, Aiko Fukuma, Takeshi Kurosu, Shumpei Watanabe, Masayuki Shimojima, Kazuya Shirato, Naoko Iwata-Yoshikawa, Noriyo Nagata, Kazuo Ohnishi, Manabu Ato, et al. Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by competitive ELISA. JOURNAL OF VIROLOGICAL METHODS. 2018. 251. 22-29

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MISC (11)：

高橋仁, 田中仁喜, 西村研吾, 高山郁代, 中内美名, 永田志保, 小林美栄, 藤博幸, 大西和夫, 横田(恒次)恭子, et al. H5HA特異的なモノクローナル抗体の作製とH5N1インフルエンザ迅速診断法構築の検討. 日本ウイルス学会学術集会プログラム・抄録集. 2013. 61st
小林(石原)美栄, 高橋仁, 西村研吾, 高山郁代, 大西和夫, 板村繁之, 影山努, 横田(恒次)恭子. H5N1インフルエンザウイルス高感度検出系開発に向けたH5HA特異的抗体のエピトープ解析. 日本ウイルス学会学術集会プログラム・抄録集. 2013. 61st
横田恭子, 大西和夫, 山本拓也. HIV感染症制圧のためのワクチン及び薬剤開発に関する研究慢性HIV感染におけるT細胞疲弊シグナルと抗原提示に関する研究. HIV感染症制圧のためのワクチン及び薬剤開発に関する研究平成23年度総括・分担研究報告書. 2012
Yu-ya Mitsuki, Kazuo Ohnishi, Hirotaka Takagi, Masamichi Oshima, Takuya Yamamoto, Fuminori Mizukoshi, Kazutaka Terahara, Kazuo Kobayashi, Naoki Yamamoto, Shoji Yamaoka, et al. A single amino acid substitution in the S1 and S2 Spike protein domains determines the neutralization escape phenotype of SARS-CoV. MICROBES AND INFECTION. 2008. 10. 8. 908-915
Yasuko Tsunetsugu-Yokota, Manabu Ato, Yoshimasa Takahashi, Shu-ichi Hashimoto, Tomohiro Kaji, Masayuki Kuraoka, Ki-ichi Yamamoto, Yu-ya Mitsuki, Takuya Yamamoto, Masamichi Oshima, et al. Formalin-treated UV-inactivated SARS coronavirus vaccine retains its immunogenicity and promotes Th2-type immune responses. JAPANESE JOURNAL OF INFECTIOUS DISEASES. 2007. 60. 2-3. 106-112

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Books (6)：

生物小事典
三省堂 2012
免疫の事典 - Dictionary of Immunology
朝倉書店 2011
Establishment and characterization of monoclonal antibodies against SARS coronavirus.
The Humana Press Inc. 2008
免疫学ハンドブック
オーム社 2005
細胞分画法
丸善 1984

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Education (2)：

1978 - 1983 University of Tsukuba
1974 - 1978 University of Tsukuba

Professional career (1)：

Ph.D. (University of Tsukuba)

Work history (6)：

2020/04 - 現在 CellSorce Co., Ltd. Research & Develoment Principal Research Fellow
2016/04 - 2020/03 Keio University Lecturer
2008/04 - 2020/03 University of Tsukuba Professor (Cooperative Graduate School Program)
1984/04 - 2020/03 National Institute of Infectious Diseases Dept. Immunology Senior Scientist
1993/01 - 1999/11 Basel Institute for Immunology Staff Scientist

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Association Membership(s) (3)：

The Japanese Society for Regenerative Medicine , THE JAPANESE SOCIETY FOR IMMUNOLOGY , The Molecular Biology Society of Japan

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