2023 - 2026 Determination of chronic or intractable mechanisms induced by low bone quality with osteomacs and bone marrow derived stem cells interaction
2023 - 2026 Development of the are treatment strategy for ORN of the jaw with Exosome derived from E-MNC
2022 - 2026 Understanding of pathophysiology and development of treatment strategy for MRONJ based on the hierarchical structure of macrophages
2022 - 2026 Understanding of pathophysiology and establishment of new treatment strategy by determining the hierarchy of macrophages in medication-related osteonecrosis of the jaw
2020 - 2023 Development of a microfluidic device for the extraction of circulating tumor cell cluster
2020 - 2023 アクチン動態に基づく臍帯由来間葉系幹細胞における骨芽細胞分化誘導法
2020 - 2023 Development of therapeutic agent for radiation salivary gland atrophy targeting the mechanism of differentiation of tissue-resident CD34-positive cells
2020 - 2023 高機能細胞治療薬E-MNCを用いた放射線性顎骨壊死の治療法の確立
2018 - 2022 Molecular targeted therapy for MRONJ
2017 - 2022 Gene activated-matrix comprised of self-assemble and multi-functional nano-devise facilitates the bone engineering
2017 - 2022 遺伝子搭載自己組織化ナノデバイスを応用した新規骨再生基質の開発
2018 - 2021 Development of treatment strategies for implant induced BRONJ in rats
2018 - 2021 The creation of bone regenerative therapy by gene activated matrix with viruses vector
2018 - 2021 高機能細胞E-MNC (CA-702)の治験開始に向けた研究開発
2017 - 2020 Autophagy-induced bone quality via oteocytes
2017 - 2020 Development of new bone regeneration method by collagen gel culture using umbilical cord MSC
2017 - 2020 Research Project for Practical Applications of Regenerative Medicine
2017 - 2019 The role of exosomes derived from mesenchymal stem cells in bone formation and regenaration
2016 - 2019 Fundamental research on the development of next generation bone tissue engineering
2015 - 2019 Direct conversion of umbilical mesenchymal stem cells facilitates the bone regeneration
2016 - 2018 Functional analysis of osteoblastic cell or immature MSC derived exosomes for bone regeneration
2016 - 2018 Development of gene-activated matrix with MSC-exosome for bone engineering
2016 - 2018 Development of novel method for bone regeneration by super-concentrated platelet with freeze-drying technique
2015 - 2018 Transplantation effect of ADSC and SVF cells on ARONJ-like lesions in mice
2014 - 2017 Immune function analysis of BRONJ mouse model and development of prophylactic therapy using regulatory T cells.
2013 - 2017 Bone engineering with gene activated-matrix and non-cultured adipose cells
2014 - 2016 Functional miRNA promotes the bone regeneration with rhBMP2 and ADCs
2013 - 2016 The investigation on salivary gland regeneration mechanisms with cell transplantation and the development of salivary gland organ regeneration
2013 - 2015 Delivery of functional microRNA accelerates the bone regeneration with BMP2 and BMAC.
2013 - 2015 Delivery of bone-marrow stem cells and functional microRNA for atrophic salivary gland regeneration
2010 - 2014 Tooth-derived mesenchymal cells as a cell replacement source in the treatment of neurological
2011 - 2012 Development of cell therapy for the salivary gland tissue regeneration with direct reprogrammed dental mesenchymal cells
2011 - 2012 Development of stem cell therapy for the oral tissues damaged by chemo-radiation therapy
2010 - 2012 Alveolar bone engineering using alveolar bone marrow derived mesenchymal stem cells
2010 - 2012 Establishment of salivary gland stem cell isolation, culture, and storage for the regeneration of salivary gland
2010 - 2012 Jaw bone regeneration using gene activated matrix incorporated withdirectly prepared adipose derived stem cells
2010 - 2011 Selection of osteogenic progenitor cells in gingival tissue
Rena Shido, Seigo Ohba, Risa Tominaga, Yoshinori Sumita, Izumi Asahina. A Prospective Study of the Assessment of the Efficacy of a Biodegradable Poly(l-lactic acid/ε-caprolactone) Membrane for Guided Bone Regeneration. Journal of clinical medicine. 2023. 12. 18
Takashi I, Riho Kanai, Kayo Hasegawa, Takunori Ogaeri, Simon D Tran, Yoshinori Sumita. Recent progress in regenerative therapy for damaged salivary glands: From bench to bedside. Oral diseases. 2023
Yuya Sakurai, Yoshinori Sumita, Masami Arai. Effectiveness of near-infrared imaging and microscopy for minimally invasive treatment of interproximal caries-Two case reports-. Journal of Digital Dentistry. 2023. 1. 1. 33-40
重度口腔乾燥をきたす唾液腺障害(放射線性唾液腺萎縮やシェーグレン症候群)に対する細胞治療開発の世界的な動向と最新の取り組み
Medical Science Digest 50(4) 75-77 2024
微細切歯髄組織の骨再生への応用
Precision Medicine 2024年1月号 2024
Adult stem cell therapy for salivary glands, with a special emphasis on mesenchymal stem cells (multipotent mesenchymal stromal cells). Salivary Gland Development and Regeneration: Advances in Research and Clinical Approaches to Functional Restoration
INTECH. 2017 ISBN:9783319435114
2015. Potential cell-based therapies for irreversibly damaged salivary glands and atrophic bone
New Trends in Tissue Engineering and Regenerative Medicine. 81-94 2015
Beta cell regeneration upon effective mononuclear cells (E-MNCs) as a possible alternative to insulin therapy
(International Society for Stem Cell Research (ISSCR) 2023 Annual Meeting 2023)
HMGB1/RAGE/TLR4 signaling is a potentiaal target for the treatment of radiation damaged salivary glands with effectively conditioned mononuclear cells (E-MNC)
(International Society for Stem Cell Research (ISSCR) 2023 Annual Meeting 2023)
2008 - Fonds de la recherche en santé du Québec (FRSQ), Network for Oral & Bone Health Research Postdoctoral Award
2004 - 歯科基礎医学会 優秀ポスター発表賞
2003 - 第二回日本再生医療学会総会 優秀演題発表賞
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Association Membership(s) (10)：
日本口腔インプラント学会
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, 国際幹細胞学会(ISSCR)
, Japanese Society of Oral Implantology
, Japanese Society for Regenerative Medicine
, International Society for Stem Cell Research (ISSCR)
, 日本口腔科学会
, IADR
, JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS
, 日本シェーグレン症候群学会
