Research field (2):
Tumor biology
, Pathobiochemistry
Research keywords (6):
腫瘍遺伝学
, 分子生物学
, 分子腫瘍学
, Cancer Genetics
, Molecular Biology
, Molecular Oncology
Research theme for competitive and other funds (21):
2020 - 2024 RB1 tumor suppressor functions in metabolism
2019 - 2022 Analysis of DIP2C as a novel regulator for epithelial-mesenchymal transition of rheumatoid arthritis synovium and a potential therapeutic target
2019 - 2021 Drug development targeting metabolic vulnerability associated with SUCLA2 loss
2017 - 2020 Metabolic regulation by RB tumor suppressor gene
2017 - 2019 Drug discovery based on collateral lethality
2017 - 2019 RB mosaicism and cell competition in mammary epithelial and cancer cells
2015 - 2017 細胞競合を介したがん幹細胞クローン維持機構
2014 - 2017 Regulation of metabolism by RB tumor suppressor gene
2014 - 2016 Inflammatory circuit that triggres malignant progression
2010 - 2012 The role of Rb-Ras pathway in cancer stem cells
2009 - 2011 Rbがん抑制遺伝子欠損によって誘導される蛋白質高イソプレニル化の研究
2008 - 2009 Analysis of cellular signals toward carcinogenesis and metastasis using genetically modified mice
2006 - 2008 RECKによるNotchシグナルの上方制御
2006 - 2007 Wild type N-ras as a tumor suppressor in human sporadic medullary thyroid cardnoma
2006 - 2007 複合変異マウスを用いたがん化・転移シグナルの研究
2005 - 2005 複合変異マウスを用いたがん化・転移シグナルの研究
2003 - 2005 野生型N-ras遺伝子の組織特異的がん抑制効果とその機構
1998 - 1998 RECK遺伝子によるがん細胞転移抑制機構の解析
1998 - 1998 フラット・リバージョン誘導遺伝子RECKによるがん転移抑制機構
がん化シグナル・がん抑制遺伝子経路と癌の悪性進展
The interaction of oncogenic signals/ tumor suppressor pathways and malignant behavior of cancer cells
Show all
Papers (88):
Nobuhiro Okada, Chihiro Ueki, Masahiro Shimazaki, Goki Tsujimoto, Susumu Kohno, Hayato Muranaka, Kiyotsugu Yoshikawa, Chiaki Takahashi. NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism. Communications biology. 2023. 6. 1. 596-596
Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao, et al. Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line. Cell death & disease. 2023. 14. 4. 241-241
Christopher Noyes, Shunsuke Kitajima, Fengkai Li, Yusuke Suita, Saradha Miriyala, Shakson Isaac, Nagib Ahsan, Erik Knelson, Amir Vajdi, Tetsuo Tani, et al. The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells. Communications Biology. 2023. 6. 1
Loc Thi Pham, Hui Peng, Masaya Ueno, Susumu Kohno, Atuso Kasada, Kazuyoshi Hosomichi, Takehiro Sato, Kenta Kurayoshi, Masahiko Kobayashi, Yuko Tadokoro, et al. RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia. Biochemical and Biophysical Research Communications. 2022. 621. 74-79
Sheng J, Kohno S, Okada N, Okahashi N, Teranishi K, Matsuda F, Shimizu S, Linn P, Nagatani N, Yamamura M, et al. Treatment of retinoblastoma 1-intact hepatocellular carcinoma with cyclin-dependent kinase 4/6 inhibitor combination therapy. 2021
2011/04 - 現在 Kanazawa University Cancer Research Institute
2009/12 - 2011/03 金沢大学がん研究所教授
2008/04 - 2009/11 京都大学医学研究科研究員
2004/01 - 2008/03 Kyoto University Graduate School of Medicine
1996/06 - 2003/12 Kyoto University Graduate School of Medicine
1999/04 - 2002/03 Harvard University
1996/04 - 1996/05 Kyoto University Graduate School of Medicine
1991/06 - 1992/03 大津赤十字病院 内科 研修医
1990/06 - 1991/05 Kyoto University
Show all
Committee career (3):
- 現在 日本癌学会 評議員
2015 - 2016 AMED プログラムオフィサー
2007 - 2011 日本病態プロテアーゼ学会 評議員
Awards (1):
2004 - 日本癌学会奨励賞
Association Membership(s) (8):
AACR
, 日本癌治療学会
, ASBMB
, JAPAN SOCIETY FOR CELL BIOLOGY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, THE JAPANESE BIOCHEMICAL SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE CANCER ASSOCIATION