Rchr
J-GLOBAL ID：201001083137128545   Update date: Oct. 21, 2024

Uchida Yasuo

ウチダ ヤスオ | Uchida Yasuo
Affiliation and department：
Hiroshima University Graduate School of Biomedical and Health Sciences

About Hiroshima University Graduate School of Biomedical and Health Sciences


Job title： Professor
Homepage URL  (2)： https://www.hiroshima-u.ac.jp/pharm/research/lab/Molecular_Systems_Pharmaceutics ,  https://www.hiroshima-u.ac.jp/en/pharm/research/lab/Molecular_Systems_Pharmaceutics
Research field  (5)： Nanobioscience ,  Biomedical engineering ,  Internal medicine - General ,  Clinical pharmacy ,  Pharmacology
Research keywords  (17)： quantitative Global Absolute Proteomics ,  DDS for CNS tissues ,  バリア制御学 ,  リズム定量プロテオミクス ,  ヒトの病態メカニズム研究 ,  パラフィン切片プロテオタイピング ,  バリアシステム生物学 ,  Pressure Cycling Technology (PCT) ,  中枢関門を介した薬物・内因性物質の輸送 ,  血液脳脊髄液関門 ,  血液クモ膜関門 ,  血液脊髄関門 ,  SWATH(次世代型定量プロテオミクス) ,  Transporters ,  Blood-brain barrier ,  ADME ,  Pharmacoproteomics
Research theme for competitive and other funds  (34)：
  • 2023 - 2027 Innovation of On-demand DDS platform of RNA therapeutics based on endothelial ATLAS
  • 2022 - 2026 Molecular basis of blood biomarkers inducing fundamental innovation in glioblastoma medicine
  • 2024 - 2026 コンパニオン診断の新領域を拓く迅速かつ高精度な分子病理診断の基盤構築
  • 2024 - 2026 Optimization of in vitro blood-brain barrier (BBB) culture system based on reconstruction of in vivo BBB ECM
  • 2023 - 2026 血液脳関門・クモ膜関門・脳脊髄液関門による脳内薬物動態の時・空間的制御機構の解明
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Papers (69)：
  • Tomoyo Yoshimori, Masashi Kawami, Yuta Kumagai, Sorahito Futatsugi, Ryoko Yumoto, Yasuo Uchida, Mikihisa Takano. Abemaciclib-induced epithelial-mesenchymal transition mediated by cyclin-dependent kinase 4/6 independent of cell cycle arrest pathway. The International Journal of Biochemistry & Cell Biology. 2024. 172. 106601-106601
  • Hana Yuasa, Naho Morino, Takumi Wagatsuma, Masayuki Munekane, Sachiko Ueda, Mayu Matsunaga, Yasuo Uchida, Takane Katayama, Toshihiko Katoh, Taiho Kambe. ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II. Journal of Biological Chemistry. 2024. 300. 6. 107378-107378
  • Shuhei Hamano, Takuya Noguchi, Yukino Asai, Ryo Ito, Ryuto Komatsu, Tetsu Sato, Aya Inoue, Tomoe Maruyama, Tada-aki Kudo, Yusuke Hirata, et al. Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. Cell Death Discovery. 2024. 10. 1
  • Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, et al. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. Journal of Medicinal Chemistry. 2023. 66. 8. 5453-5464
  • Yi Wang, Maki Sakaguchi, Hemragul Sabit, Sho Tamai, Toshiya Ichinose, Shingo Tanaka, Masashi Kinoshita, Yasuo Uchida, Sumio Ohtsuki, Mitsutoshi Nakada. COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion. Journal of Neurosurgery. 2023. 138. 3. 639-648
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MISC (32)：
  • 赤井美月, 川見昌史, 内田康雄. SWATH-MS法を利用した金属輸送体の機能解析. 生体の科学. 2024. 75. 2. 116-121
  • 前田祐希, 川見昌史, 内田康雄. 血液クモ膜関門: 血液脳関門とは異なる輸送分子機構をもつ新たな中枢関門. 膜(MEMBRANE). 2024. 49. 2. 99-106
  • 内田康雄. 次世代型定量プロテオミクスによる中枢関門トランスポーター研究. 薬剤学. 2023. 83. 2. 72-77
  • 赤川ラリブレダ, 内田康雄. 輸送に関わる分子とその機能. 中外医学社Clinical Neuroscience. 2022. 40. 12
  • 4つの中枢関門の分子機構の解明に基づくヒトの脳内薬物濃度の予測と中枢疾患の新たな創薬フィールドの開拓. 2020
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Books (5)：
  • Blood-arachnoid barrier as a dynamic physiological and pharmacological interface between cerebrospinal fluid and blood
    2022
  • Recent progress in blood-brain barrier and blood-CSF barrier transport research: Pharmaceutical relevance for drug delivery to the brain. IN Drug Delivery to the Brain - Physiological Concepts, Methodologies and Approaches, Margareta Hammarlund-Udenaes, E
    Springer, pp 23-62 2014
  • Chapter 10 Pharmacoproteomics. IN Essential Manual for Pharmaceutical Experiment, Y Watanabe, Y Deguchi and K Ito (Ed.)
    Nankodo Co., Ltd. Tokyo, pp312-324 2014
  • Blood-brain barrier (BBB) pharmacoproteomics: a new research field opened up by quantitative targeted absolute proteomics (QTAP). IN Drug Delivery to the Brain - Physiological Concepts, Methodologies and Approaches, Margareta Hammarlund-Udenaes, Elizabeth
    Springer, pp 63-100 2014
  • The role of drug transporters at blood-brain barrier. IN The World of Transportsome -From Headstream of Membrane Transport Research to the Future-, Y Kanai, H Takeshima, Y Mori and Y Kubo (Ed.)
    Kyoto Hirokawa Publishing Inc. Tokyo, pp282-290 2011
Lectures and oral presentations  (46)：
  • パラフィン切片を用いた定量プロテオミクス: どのように効率的なタンパク質抽出を実現するか
    (日本プロテオーム学会2024年大会・ 第20回日本臨床プロテオゲノミクス学会 合同大会 2024)
  • 脳神経疾患治療を標的とする中枢関門と脳内病態の定量プロテオミクス研究
    (日本薬剤学会第39年会 2024)
  • 日本が誇るブレインバンクのヒト脳組織を活用した病態プロテオミクス研究
    (日本薬学会第144年会 2024)
  • Next Generation Quantitative Proteomicsによって拓かれる中枢関門研究の新展開
    (第149 回 日本薬学会中四国支部例会 2024)
  • 定量プロテオミクスに基づく薬物輸送研究
    (創薬動態フォーラムin金沢 2024)
ｍore...
Education (2)：
  • - 2010 Tohoku University Graduate School, Division of Pharmaceutical Sciences 医療薬科学専攻
  • - 2006 Tohoku University Faculty of Pharmaceutical Science 総合薬学科
Professional career (1)：
  • Ph.D. (Tohoku University)
Work history (7)：
  • 2023/04 - 現在 Graduate School of Biomedical and Health Sciences, Hiroshima University Professor
  • 2023/03 - 2023/03 Graduate School of Pharmaceutical Sciences Associate Professor
  • 2018/09 - 2023/02 Graduate School of Pharmaceutical Sciences lecturer
  • 2012/02 - 2018/08 Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University Assistant Professor
  • 2014/04 - 2016/03 Institute of Molecular Systems Biology, ETH Zurich (Prof Ruedi Aebersold group) (JSPS postdoctoral fellow for research abroad) JSPS postdoctoral fellow for research abroad Visiting Scientist
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Committee career (9)：
  • 2008/04 - 現在 トランスポーター研究会 幹事
  • - 現在 日本薬剤学会 代議員
  • - 現在 Journal of Neurochemistry Editor
  • - 現在 Molecular Pharmaceutics Editorial Advisory Board
  • - 現在 Journal of Pharmaceutical Sciences Editorial Advisory Board
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Awards (17)：
  • 2023/04 - The Young Scientists’ Award, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
  • 2022/04 - CREST細胞外微粒子Young Innovator Award
  • 2020/11 - Journal of Pharmaceutical Sciences Top reviewer award
  • 2020/03 - 日本薬学会 2020年度日本薬学会奨励賞 「定量プロテオミクスに基づく血液脳関門の輸送機能および病態変動機構の解明」
  • 2018/07 - 平成30年度東北大学大学院薬学研究科長賞
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Association Membership(s) (9)：
Japan Transporter Research Association ,  The Pharmaceutical Society of Japan ,  The Academy of Pharmaceutical Science and Technology, Japan ,  The Japanese Society for the Study of Xenobiotics ,  Human Proteome Organization ,  International Society for the Study of Xenobiotics ,  American Association of Pharmaceutical Scientists ,  International Brain Barriers Society ,  International Society for Neurochemistry
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