Rchr
J-GLOBAL ID:201001087084049210   Update date: Mar. 12, 2024

TAKEO NAKANISHI

ナカニシ タケオ | TAKEO NAKANISHI
Affiliation and department:
Job title: Associate Professor
Homepage URL  (2): https://www.molecularkinetics.org/https://www.molecularkinetics.org/english
Research field  (3): Pharmacology ,  Molecular biology ,  Clinical pharmacy
Research keywords  (9): Membrane Transporter ,  Transporter ,  Multi-drug Resistance ,  Nutritional Signaling ,  plasma membranes ,  Organic anion transporting polypeptides ,  pharmacology ,  prostaglandin ,  pharmacokinetics
Research theme for competitive and other funds  (12):
  • 2020 - 2023 An implication of transporter-mediated regulation of brain PG concentration for mental diseases
  • 2015 - 2018 プロスタグランジン輸送体を基盤とする肺線維化とその抑制手法に関する研究
  • 2016 - 2017 マイクロRNAによるOATP輸送体の発現調節機構に基づく薬物療法最適化
  • 2015 - 2016 癌関連トランスポーター発現解析に基づく機能性分子発現系による腫瘍診断薬の開発戦略
  • 2015 - 2016 プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱
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Papers (218):
  • Yoshinobu Nakamura, Masa-aki Ito, Yukino Hoshino, Isao Matsuoka, Toshiaki Okada, Yasunobu Okada, Takeo Nakanishi. Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10. American Journal of Physiology-Cell Physiology. 2024
  • Takeo Nakanishi, Yuki Kawasaki, Yoshinobu Nakamura, Yuuki Kimura, Kotone Kawamura, Melody N. Shumba, Noriaki Shimokawa. An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD. Experimental Cell Research. 2023. 431. 1. 113740-113740
  • Yoshinobu Nakamura, Chisato Aizawa, Hinako Kawata, Takeo Nakanishi. N-glycosylation modifies prostaglandin E2 uptake by reducing cell surface expression of SLCO2A1. Prostaglandins & Other Lipid Mediators. 2023. 165. 106714-106714
  • Kakeru Sato, Asuka Mizutani, Yuka Muranaka, Jianwei Yao, Masato, Kobayashi, Kana Yamazaki, Ryuichi Nishii, Kodai Nishi, Takeo Nakanishi, et al. Biological Distribution after Oral Administration of Radioiodine-labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs and/or MRPs. Pharmaceutics,. 2023. 15. 2. 497
  • Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, et al. A Single High-Dose Irradiation Changes Accumulation of Methotrexate and Gene Expression Levels of SLC and ABC Transporters in Cancer Cells. Frontiers in Pharmacology. 2023. 13. 1069321-1069321
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MISC (10):
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Patents (2):
  • 細胞増殖性疾患の治療用または診断用薬剤
  • 分子イメージングにより代謝機能を測定するための検査薬
Books (8):
  • Development of Formulations and Devices of Next-Generation Inhalations
    2018 ISBN:9784781313535
  • RSC Drug Discovery Series No. 54 Drug Transporters: Volume 1 Role and Importance in ADME and Drug Development
    The Royal Society of Chemistry 2016 ISBN:9781782620693
  • DDS製剤の開発・評価と実用化手法
    技術情報協会 2013
  • Transporters in drug discovery, development and use
    Aaps Press/Springer 2013
  • Springer Protocol-Membrane transporters in drug discovery and development. Methods and Protocols
    Humana Press/Springer Science/Business Media 2010
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Lectures and oral presentations  (178):
  • Unappreciated roles of organic anion transporting polypeptides (OATPs) in human diseases
    (University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Hormone-Responsive Cancer Program Special Seminar 2017)
  • 肺線維症モデルを用いた炎症におけるプロスタグランジン輸送体OATP2A1の役割の検討
    (第38回生体膜と薬物の相互作用シンポジウム 2016)
  • Attenuation of endotoxin-induced fever in prostaglandin transporter OATP2A1 global and macrophage-specific knockout mice.
    (2016)
  • Involvement of intestinal transporter OATP2B1 in gastrointestinal toxicity induced by SN-38, an active metabolite of anticancer irinotecan
    (2016)
  • 炎症性疾患におけるプロスタグランジントランスポーターの新規役割
    (日本薬物動態学会31年会 2016)
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Education (3):
  • 1999 - Kanazawa University
  • 1996 - Kanazawa University Graduate School, Division of Pharmaceutical Sciences
  • 1994 - Kyoto Institute of Technology
Professional career (3):
  • 工学士 (京都工芸繊維大学)
  • 修士(薬学) (金沢大学)
  • 博士(薬学) (金沢大学)
Work history (6):
  • 2019/04 - 現在 Takasaki University of Health and Welfare Faculty of Pharmacy
  • 2008/12 - 2019/03 Kanazawa University
  • 2005/05/31 - 2008/11/30 University of Maryland Research Associate
  • 2001/03/01 - 2005/05/30 University of Maryland Post-doctoral Fellow
  • 2000/04 - 2001/02 Medical College of Georgia Post-doctoral Fellow Medical College of Georgia
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Committee career (15):
  • 2021/02 - 現在 Frontiers in Pharmacology Associate Editor
  • 2020/11 - 現在 日本薬学会 代議員
  • 2019/01 - 現在 ”Cancer Communications” Editorial Board Member
  • 2018/11 - 現在 ”Cancers” Editorial Board Member
  • 2017/04 - 現在 ”Drug Metabolism and Pharmacokinetics” Editorial Advisory Board Member
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Awards (8):
  • 2017/12 - Effect of Fruit-derived Nanoparticle on Intestinal Transporters 32nd JSSX Best Poster Award
  • 2017/11 - 2017 Top Reviewer in Journal of Pharmaceutical Sciences
  • 2016/11 - 2016 Top Reviewer in Journal of Pharmaceutical Sciences
  • 2015/11 - Chinese Journal Cancer 最優秀論文賞
  • 2012/11/21 - JSSX Young Investigator Award
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Association Membership(s) (5):
Japanese Conference on the Bioscience of Lipids ,  日本DDS学会 ,  日本薬剤学会 ,  Japanese Society for Study of Xenobiotics ,  日本薬学会
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