TAKEO NAKANISHI

ナカニシタケオ | TAKEO NAKANISHI

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://www.molecularkinetics.org/ , https://www.molecularkinetics.org/english

Research field (3)： Pharmacology , Molecular biology , Clinical pharmacy

Research keywords (9)： Membrane Transporter , Transporter , Multi-drug Resistance , Nutritional Signaling , plasma membranes , Organic anion transporting polypeptides , pharmacology , prostaglandin , pharmacokinetics

Research theme for competitive and other funds (12)：

2020 - 2023 An implication of transporter-mediated regulation of brain PG concentration for mental diseases
2015 - 2018 プロスタグランジン輸送体を基盤とする肺線維化とその抑制手法に関する研究
2016 - 2017 マイクロRNAによるOATP輸送体の発現調節機構に基づく薬物療法最適化
2015 - 2016 癌関連トランスポーター発現解析に基づく機能性分子発現系による腫瘍診断薬の開発戦略
2015 - 2016 プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱

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Papers (220)：

Hiroaki Shimada, Akito Yokotobi, Nonoka Yamamoto, Mao Takada, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki. Inhibition of 15-prostaglandin dehydrogenase attenuates acetaminophen-induced liver injury via suppression of apoptosis in liver endothelial cells. Prostaglandins, leukotrienes, and essential fatty acids. 2024. 202. 102640-102640
Yoshinobu Nakamura, Masa-aki Ito, Yukino Hoshino, Isao Matsuoka, Toshiaki Okada, Yasunobu Okada, Takeo Nakanishi. Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10. American Journal of Physiology-Cell Physiology. 2024
Takeo Nakanishi, Yuki Kawasaki, Yoshinobu Nakamura, Yuuki Kimura, Kotone Kawamura, Melody N. Shumba, Noriaki Shimokawa. An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD. Experimental Cell Research. 2023. 431. 1. 113740-113740
Yoshinobu Nakamura, Chisato Aizawa, Hinako Kawata, Takeo Nakanishi. N-glycosylation modifies prostaglandin E2 uptake by reducing cell surface expression of SLCO2A1. Prostaglandins & Other Lipid Mediators. 2023. 165. 106714-106714
Kakeru Sato, Asuka Mizutani, Yuka Muranaka, Jianwei Yao, Masato, Kobayashi, Kana Yamazaki, Ryuichi Nishii, Kodai Nishi, Takeo Nakanishi, et al. Biological Distribution after Oral Administration of Radioiodine-labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs and/or MRPs. Pharmaceutics,. 2023. 15. 2. 497

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MISC (10)：

中西猛夫, 玉井郁巳. 尿酸排泄トランスポーター BCRPの特徴と尿酸輸送メカニズム. 尿酸と血糖. 2017. 3. 1. 22-27
Role of Transporters in Pulmonary Disposition of Drugs and Endogenous Compounds. 2015. 44. 1. 38-46
松本准, 有吉範高, 榊原雅裕, 中西猛夫, 石井伊都子, 山田治美, 武田弘志. 新規創薬ターゲットおよびバイオマーカーの確立を目指した乳がんにおけるestrogen前駆体の取り込み機構の解明. 国際医療福祉大学学会誌. 2014. 19. 抄録号. 59-59
奥平宏之, 岡俊太郎, 中西猛夫, 小林正和, シャスターデービッド, グッドマンマーク, 玉井郁巳, 川井恵一, 白神宜史. 前立腺癌へのtrans-1-amino-3-18F-fluorocyclobutanecarboxylic acid(anti-18F-FACBC)の輸送機序. 日本DDS学会学術集会プログラム予稿集. 2014. 30th
Takeo Nakanishi, Ikumi Tamai. Oral drug delivery targeting intestinal transporter. Drug Delivery System. 2012. 27. 5. 350-360

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Patents (2)：

細胞増殖性疾患の治療用または診断用薬剤
分子イメージングにより代謝機能を測定するための検査薬

Books (8)：

Development of Formulations and Devices of Next-Generation Inhalations
2018 ISBN:9784781313535
RSC Drug Discovery Series No. 54 Drug Transporters: Volume 1 Role and Importance in ADME and Drug Development
The Royal Society of Chemistry 2016 ISBN:9781782620693
DDS製剤の開発・評価と実用化手法
技術情報協会 2013
Transporters in drug discovery, development and use
Aaps Press/Springer 2013
Springer Protocol-Membrane transporters in drug discovery and development. Methods and Protocols
Humana Press/Springer Science/Business Media 2010

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Lectures and oral presentations (177)：

Unappreciated roles of organic anion transporting polypeptides (OATPs) in human diseases
(University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Hormone-Responsive Cancer Program Special Seminar 2017)
肺線維症モデルを用いた炎症におけるプロスタグランジン輸送体OATP2A1の役割の検討
(第38回生体膜と薬物の相互作用シンポジウム 2016)
Attenuation of endotoxin-induced fever in prostaglandin transporter OATP2A1 global and macrophage-specific knockout mice.
(2016)
Involvement of intestinal transporter OATP2B1 in gastrointestinal toxicity induced by SN-38, an active metabolite of anticancer irinotecan
(2016)
炎症性疾患におけるプロスタグランジントランスポーターの新規役割
(日本薬物動態学会31年会 2016)

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Education (3)：

1999 - Kanazawa University
1996 - Kanazawa University Graduate School, Division of Pharmaceutical Sciences
1994 - Kyoto Institute of Technology

Professional career (3)：

工学士 (京都工芸繊維大学)
修士(薬学) (金沢大学)
博士(薬学) (金沢大学)

Work history (6)：

2019/04 - 現在 Takasaki University of Health and Welfare Faculty of Pharmacy
2008/12 - 2019/03 Kanazawa University
2005/05/31 - 2008/11/30 University of Maryland Research Associate
2001/03/01 - 2005/05/30 University of Maryland Post-doctoral Fellow
2000/04 - 2001/02 Medical College of Georgia Post-doctoral Fellow Medical College of Georgia

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Committee career (15)：

2021/02 - 現在 Frontiers in Pharmacology Associate Editor
2020/11 - 現在日本薬学会代議員
2019/01 - 現在 ”Cancer Communications” Editorial Board Member
2018/11 - 現在 ”Cancers” Editorial Board Member
2017/04 - 現在 ”Drug Metabolism and Pharmacokinetics” Editorial Advisory Board Member

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Awards (8)：

2017/12 - Effect of Fruit-derived Nanoparticle on Intestinal Transporters 32nd JSSX Best Poster Award
2017/11 - 2017 Top Reviewer in Journal of Pharmaceutical Sciences
2016/11 - 2016 Top Reviewer in Journal of Pharmaceutical Sciences
2015/11 - Chinese Journal Cancer 最優秀論文賞
2012/11/21 - JSSX Young Investigator Award

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Association Membership(s) (5)：

Japanese Conference on the Bioscience of Lipids , 日本DDS学会 , 日本薬剤学会 , Japanese Society for Study of Xenobiotics , 日本薬学会

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