Rchr
J-GLOBAL ID：201001090728955200
Update date: Apr. 11, 2024
Fujiwara Kyoko
フジワラ キョウコ | Fujiwara Kyoko
Affiliation and department：
Job title：
Associate Professor
Research field (4)：
Cell biology
, Molecular biology
, Tumor diagnostics and therapeutics
, Tumor biology
Research keywords (3)：
呼吸鎖複合体阻害剤
, がん感受性遺伝子
, 骨芽細胞の分化メカニズム
Research theme for competitive and other funds (17)：
- 2022 - 2025 新規化合物PEG-XのTP53変異細胞特異的な抗腫瘍効果の機序の解明
- 2020 - 2023 PIポリアミドによる低酸素細胞に対する放射線増感剤の開発
- 2020 - 2023 Molecular approaches to identify the novel therapeutic targets for the encephalitis associated with neuronal surface antibodies
- 2019 - 2022 Discovery of PI polyamide targeting androgen receptor collaborative transcriptional factor in castration-resistant prostate cancer
- 2018 - 2021 糸状菌由来ポリエチレングリコール誘導体による腫瘍特異的な細胞障害性の機序の解明
- 2016 - 2020 Development of the alkylating agent targeting intrahepatic cholangiocarcinoma -specific fusion gene
- 2016 - 2019 Examination of differentiation induction new therapy using DFAT in human neuroblastoma
- 2015 - 2018 The elucidation on androgen signaling pathway in prostate cancer and development of its targeting drug
- 2015 - 2018 Mechanistic study on tumor-selective killing by plasma
- 2015 - 2018 Anti-tumor effect of alkylating pyrrole-imidazole polyamide targeting rhabdomyosarcoma specific fusion gene PAX3-FOXO1
- 2015 - 2018 ヒト有棘細胞癌関連遺伝子変異の解析-ヒストン脱メチル化酵素欠損マウスを用いた探索
- 2014 - 2017 Analaysys of tumor-associated genes in human pediatric liver tumor and renal tumor using mice at each developmental stage
- 2014 - 2017 Searching for tumor associated genes of human nephroblastoma and human hepatoblastoma by analysis of tumor specific genes
- 2012 - 2015 Development of new radiosensitizer for osteosarcoma
- 2012 - 2015 ヒト有棘細胞癌におけるゲノムメチル化変異の解析
- 2011 - 2013 Analysis of anti-cancer effect of PI polyamide, which suppress MYC downstream genes
- 2010 - 2012 Investigation of Imprinting mechanism between Beckwith-Wiedemann syndrome and Wilms tumor
Show all
Papers (63)：
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Ryo Sakai, Kyoko Fujiwara, Eri Nagasaki-Maeoka, Yoshinori Inagaki, Bin Yamaoka, Eri Muto-Fujita, Yusuke Kamidaki, Tsugumichi Koshinaga, Shuichiro Uehara, Tadateru Takayama, et al. Knockdown of TFAP2E results in rapid G2/M transition in oral squamous cell carcinoma cells. Oncology letters. 2024. 27. 3. 128-128
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Natsuo Shimizu, Kyoko Fujiwara, Kotoe Mayahara, Mitsuru Motoyoshi, Tomihisa Takahashi. Tension force causes cell cycle arrest at G2/M phase in osteocyte-like cell line MLO-Y4. Heliyon. 2023. 9. 2. e13236-e13236
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Daigo Funakoshi, Daisuke Obinata, Kyoko Fujiwara, Shinichiro Yamamoto, Kenichi Takayama, Makoto Hara, Satoru Takahashi, Satoshi Inoue. Antitumor effects of pyrrole-imidazole polyamide modified with alkylating agent on prostate cancer cells. Biochemical and biophysical research communications. 2022. 623. 9-16
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Sato K, Osaka E, Fujiwara K, Fujii R, Takayama T, Tokuhashi Y, Nakanishi K. miRNA-218 targets multiple oncogenes and is a therapeutic target for osteosarcoma. Oncology Reports. 2022. 47. 5. 92
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Bin Yamaoka, Eri Nagasaki-Maeoka, Shota Uekusa, Ayano Hidaka, Kohei Hijikata, Reona Kato, Kyoko Fujiwara, Tsugumichi Koshinaga, Shuichiro Uehara. Exosomal miR-214-3p as a potential novel biomarker for rhabdoid tumor of the kidney. Pediatric surgery international. 2021. 37. 12. 1783-1790
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MISC (47)：
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Nagasaki Eri, Ikeda Kazuhiro, Takayama Kenichi, Hirano Takayuki, Ishizuka Yoshiaki, Koshinaga Tsugumichi, Tsukune Naoya, Takayama Tadateru, Inoue Satoshi, Fujiwara Kyoko. ポリエチレングリコール誘導体9bwは酸化的リン酸化を阻害して神経芽腫細胞の増殖を抑制する(Polyethylene glycol derivative 9bw suppresses growth of neuroblastoma cells by inhibiting oxidative phosphorylation). 日本小児血液・がん学会雑誌. 2020. 57. 4. 249-249
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大日方 大亮, 高山 賢一, 藤原 恭子, 山本 慎一郎, 高田 将吾, 芦苅 大作, 井上 聡, 高橋 悟. 泌尿器科領域における基礎研究の成果 アンドロゲン受容体(AR)活性増強因子の去勢抵抗性前立腺癌(CRPC)における役割. 泌尿器外科. 2019. 32. 臨増. 597-598
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平野 隆幸, 長崎 瑛里, 石塚 悦昭, 星 玲奈, 吉澤 信輔, 植草 省太, 川島 弘之, 金田 英秀, 古屋 武史, 大橋 研介, et al. 神経芽腫におけるNR4A3と神経分化の検討. 日本小児外科学会雑誌. 2018. 54. 3. 811-811
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平野 隆幸, 長崎 瑛里, 石塚 悦昭, 星 玲奈, 渡邉 揚介, 吉澤 信輔, 植草 省太, 川島 弘之, 金田 英秀, 古屋 武史, et al. 神経芽腫の分化におけるNR4A3遺伝子の解析. 日本外科学会定期学術集会抄録集. 2018. 118回. 1000-1000
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長崎 瑛里, 平野 隆幸, 石塚 悦昭, 渡邉 揚介, 星 玲奈, 吉澤 信輔, 植草 省太, 川島 弘之, 金田 英秀, 古屋 武史, et al. 新規ポリエチレングリコール誘導体PEG-Xによる抗腫瘍効果の検討. 日本外科学会定期学術集会抄録集. 2018. 118回. 2120-2120
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Patents (7)：
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新規PIポリアミド
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新規PIポリアミド
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新規PIポリアミド
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新規PIポリアミド
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新規PIポリアミド
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Professional career (1)：
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