Ishikawa Fumihiro

イシカワフミヒロ | Ishikawa Fumihiro

Affiliation and department：
Job title： Associate professor

Research field (4)： Experimental pathology , Pathobiochemistry , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (2)：分子腫瘍学 , 分子細胞生物学

Research theme for competitive and other funds (10)：

2022 - 2025 転移抑制を目指したRac1によるintegrin β4の分解抑制機構の解明
2021 - 2025 Respiratory chain activity as a target of tumor-agnostic therapy in highly glycolytic/low respiratory tumors
2019 - 2022 Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels
2018 - 2021 転写制御因子SUZ12によるレドックス制御を介した足場非依存性増殖機構の解析
2015 - 2018 A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells

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Papers (68)：

Yuki Tomitsuka, Hiroki Imaeda, Haruka Ito, Isaki Asou, Masayuki Ohbayashi, Fumihiro Ishikawa, Hiroshi Kuwata, Shuntaro Hara. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation. Redox biology. 2023. 66. 102850-102850
Hidetsugu Nakagawa, Masato Higurashi, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma. An indispensable role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in basal-like triple-negative breast cancer cells. Biochemical and biophysical research communications. 2023. 649. 1-9
Shigetoshi Nishihara, Toshimitsu Yamaoka, Fumihiro Ishikawa, Kensuke Higuchi, Yuki Hasebe, Ryo Manabe, Yasunari Kishino, Sojiro Kusumoto, Koichi Ando, Yusuke Kuroda, et al. Mechanisms of EGFR-TKI-Induced Apoptosis and Strategies Targeting Apoptosis in EGFR-Mutated Non-Small Cell Lung Cancer. Genes. 2022. 13. 12
Tsuyoshi Maruyama, Koji Saito, Masato Higurashi, Fumihiro Ishikawa, Yohko Kohno, Kazunori Mori, Motoko Shibanuma. HMGA2 drives the IGFBP1 / AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA / RNA -less cancer cells. Cancer Science. 2022. 114. 1. 152-163
中川英嗣, 石川文博, 森一憲, 柴沼質子. 乳癌細胞の足場非依存性生存におけるTAZの役割(Role of TAZ in promoting cell survival upon anchorage loss in breast cancer cells). 日本癌学会総会記事. 2022. 81回. P-1151

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MISC (13)：

日暮大渡, 森一憲, 中川英嗣, 石川文博, 柴沼質子. A role of NAD⁺-SIRT3/6 axes in control of p21^Cip1 expression and cancer cell proliferation. 日本癌学会学術総会抄録集(Web). 2023. 82nd
中川英嗣, 森一憲, 日暮大渡, 石川文博, 柴沼質子. Stabilization of the oncogene TAZ by the deubiquitinating enzyme OTUB1 contributes to anchorage-independent cell survival in breast cancer cells. 日本薬学会年会要旨集(Web). 2023. 143rd
西原成俊, 山岡利光, 長谷部友紀, 石川文博, 楠本壮二郎, 大森亨, 相良博典, 吉田仁, 鶴谷純司. 肺腺癌細胞における第3世代EGFR-TKIオシメルチニブの獲得耐性機序の検討(Resistance mechanisms against osimertinib in lung adenocarcinoma cells with EGFR-activating mutation). 日本癌学会総会記事. 2022. 81回. P-2365
石野敬子, 宇高結子, 岩瀬万里子, 小山田英人, 石川文博, 田中大介, 木内祐二. 昭和大学病院 PCR センターで実施した SARS-CoV-2 学生スクリーニング検査. 日本薬学会第142年会. 2022. 142年会. 26M-pm18
木内祐二, 小山田英人, 石野敬子, 石川文博, 宇髙結子. 新型コロナウイルスと分析化学医療系大学の基礎系教員の支援により開設した"新型コロナウイルス対応PCRセンター"の活動. ぶんせき / 日本分析化学会編. 2020. 2020. 12. 485-489

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Lectures and oral presentations (1)：

Polycomb-group protein SUZ12 suppresses anoikis by alleviating oxidative stress in cancer cells
(第143回日本薬学会年会 2023)

Professional career (1)：

Work history (4)：

Association Membership(s) (2)：

日本分子生物学会 , 日本癌学会

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