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J-GLOBAL ID：201002203222445397   Reference number：10A0380243

Involvement of metallothionein (MT) as a biological protective factor against carcinogenesis induced by benzo[a]pyrene (B[a]P)

ベンゾ[a]ピレン(B[a]P)により誘発された発癌に対する生物学的保護因子としてのメタロチオネイン(MT)の関与

Author (6)： TAKAISHI Masaki (Lab. of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical Univ.) ,  SHIMADA Akinori (Dep. of Veterinary Pathology, Tottori Univ.) ,  SUZUKI Junko S. (Res. Center for Environmental Risk, National Inst. for Environmental Studies) ,  SATOH Masahiko (Lab. of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical Univ.) ,  SATOH Masahiko (Lab. of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Univ.) ,  NAGASE Hisamitsu (Lab. of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical Univ.)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 35  Issue： 2  Page： 225-230 (J-STAGE)  Publication year： 2010 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： carcinogen ,...
Semi thesaurus term： Metallothionein I ,...

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JST classification (3)： Condensed tetra-or more-cyclic carbocyclic compounds  (CF06090C) ,  Carcinogenic mechanisms and factors  (GE02020C) ,  Enzyme physiology  (EJ02020P)

Substance index (1)： Benzo(a)pyrene

Reference (43)：

• BADARY, O. A. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur. J. Cancer Prev. 1999, 8, 435-400
• CHIAPPERINO, D. Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. J. Biol. Chem. 2005, 280, 39684-39692
• CHUBATSU, L. S. Metallothionein protects DNA from oxidative damage. Biochem. J. 1993, 291, 193-198
• COYLE, P. Metallothionein : the multipurpose protein. Cell. Mol. Life Sci. 2002, 59, 627-647
• DUNCAN, J. R. Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice. J. Natl. Cancer Inst. 1975, 55, 195-196

Terms in the title (7)： ピレン ,  誘発 ,  発癌 ,  生物学 ,  因子 ,  メタロチオネイン ,  Mt