Art

J-GLOBAL ID：201002209735916830   Reference number：10A0151077

Akt活性を修飾する新しい分子標的の探索

Author (1)： MIZUTSU FUTOSHI (北大 遺伝子病制御研)
Material： 上原記念生命科学財団研究報告集(CD-ROM)
Volume： 23  Page： ROMBUNNO.112  Publication year： 2009 
JST Material Number： J1247B  ISSN： 2433-3441  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *serine-threonine kinase ,...
Semi thesaurus term： *Akt ,...

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JST classification (1)： Enzyme physiology  (EJ02020P)

Reference (5)：

• Chan, T. O., Rittenhouse, S. E.& Tsichlis, P. N.: AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu. Rev. Biochem., 68: 965-1014, 1999.
• Hiromura, M., Okada, F., Obata, T., Auguin, D., Shibata, T., Roumestand, C.& Noguchi, M.: Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. J. Biol. Chem., 279: 53407-53418, 2004.
• Noguchi, M., Ropars, V., Roumestand, C.& Suizu, F.: Proto-oncogene TCL1: more than just a coactivator for Akt. FASEB J., 21: 2273-2284, 2007.
• Suizu, F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A. J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse C., Hatakeyama, S., Obata, T.& Noguchi, M.: An E3 ligase TTC3 that facilitates ubiquitination and degradation of phosphorylated Akt. Dev. Cell, in press, 2009.
• Saran, N. G., Pletcher, M. T., Natale, J. E., Cheng, Y.& Reeves, R. H.: Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum. Mol. Genet., 12: 2013-2019, 2003.

Terms in the title (5)： Akt ,  活性 ,  修飾 ,  分子標的 ,  探索