Art

J-GLOBAL ID：201002212983343619   Reference number：10A1120957

Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)

非扁平非小細胞肺癌の第1選択療法としてのシスプラチン-ゲムシタビンおよびベバシズマブまたはプラセボでの全生存率 無作為化第III相試験の結果(AVAiL)

Author (11)： RECK M. (Krankenhaus Grosshansdorf, Grosshansdorf) ,  VON PAWEL J. (Asklepios Fachkliniken, Muenchen-Gauting, DEU) ,  ZATLOUKAL P. (Charles Univ., Prague, CZE) ,  RAMLAU R. (Wielkopolskie Centrum Chorob Pluc i Gruzlicy, Poznan, POL) ,  GORBOUNOVA V. (Russian Cancer Res. Center, Moscow, RUS) ,  HIRSH V. (McGill Univ. Health Centre, Montreal) ,  LEIGHL N. (Princess Margaret Hospital, Toronto, CAN) ,  MEZGER J. (St Vincentius-Kliniken, Karlsruhe, DEU) ,  ARCHER V. (F. Hoffmann-La Roche Ltd, Welwyn Garden City, GBR) ,  MOORE N. (F. Hoffmann-La Roche Ltd, Basel, CHE) ,  MANEGOLD C. (Heidelberg Univ. Medical Center, Mannheim, DEU)
Material： Annals of Oncology  (Ann Oncol)
Volume： 21  Issue： 9  Page： 1804-1809  Publication year： Sep. 2010 
JST Material Number： W0107A  ISSN： 0923-7534  CODEN： ANONE2  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *non-small cell lung cancer ,...

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JST classification (2)： Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (1)： Gemcitabine

Reference (17)：

• Smit EF, van Meerbeeck JP, Lianes P et al. Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced nonsmall- cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975. J Clin Oncol 2003; 21: 3909-3917.
• Le Chevalier T, Scagliotti G, Natale R et al. Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. Lung Cancer 2005; 47: 69-80.
• Ferrara N, Hillan KJ, Gerber HP et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3: 391-400.
• Presta LG, Chen H, O’Connor SJ et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-4599.
• Hurwitz H, Fehrenbacher L, Novotny W. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350: 2335-2342.

Terms in the title (9)： 扁平 ,  非小細胞肺癌 ,  療法 ,  シスプラチン ,  ゲムシタビン ,  ベバシズマブ ,  プラセボ ,  全生存率 ,  第III相試験