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J-GLOBAL ID：201002215429209829   Reference number：10A0035304

Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus

Streptomyces griseusにおけるrsmG突然変異の発生による二次代謝物-生合成遺伝子クラスターの活性化

Author (4)： TANAKA Yukinori (National Food Res. Inst., Ibaraki, JPN) ,  TANAKA Yukinori (Shizuoka Univ., Shizuoka, JPN) ,  TOKUYAMA Shinji (Shizuoka Univ., Shizuoka, JPN) ,  OCHI Kozo (National Food Res. Inst., Ibaraki, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 62  Issue： 12  Page： 669-673  Publication year： Dec. 2009 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Streptomyces griseus ,...
Semi thesaurus term： *rsmG ,...

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JST classification (1)： Antibiotic-producing microorganisms  (GX02000L)

Substance index (1)： Streptomycin

Reference (20)：

• NEWMAN, D. J. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 2007, 70, 461-477
• BENTLEY, S. D. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002, 417, 141-147
• IKEDA, H. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 2003, 21, 526-531
• OHNISHI, Y. Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO13350. J. Bacteriol. 2008, 190, 4050-4060
• NISHIMURA, K. Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). J. Bacteriol. 2007, 189, 3876-3883

Terms in the title (6)： Streptomyces ,  突然変異 ,  二次代謝物 ,  生合成遺伝子 ,  クラスター ,  活性化