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J-GLOBAL ID：201002215787754162   Reference number：10A0839436

siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells

siRNA-媒介性AMPKα1サブユニット遺伝子PRKAA1サイレンシングは,HEK293細胞において,メチル水銀毒性を増強する

Author (8)： HWANG Gi-wook (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  TOBITA Mayumi (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  TAKAHASHI Tsutomu (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  KUGE Shusuke (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  KUGE Shusuke (Dep. of Microbiology, Tohoku Pharmaceutical Univ.) ,  KITA Kayoko (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  KITA Kayoko (Lab. of Toxicology, Fac. of Pharmaceutical Sciences, Teikyo Univ.) ,  NAGANUMA Akira (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 35  Issue： 4  Page： 601-604 (J-STAGE)  Publication year： 2010 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： HEK293 cell ,...
Semi thesaurus term： *AMP-Activated Protein Kinases ,...

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JST classification (1)： Toxicity of metals and metal compounds  (GZ02022V)

Substance index (1)： Methylmercury

Reference (17)：

• Carling, D. (2004): The AMP-activated protein kinase cascade--a unifying system for energy control. Trends Biochem. Sci., 29, 18-24.
• Clarkson, T.W. and Magos, L. (2006): The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol., 36, 609-662.
• Furuchi, T., Hwang, G.W. and Naganuma, A. (2002): Overexpression of the ubiquitin-conjugating enzyme Cdc34 confers resistance to methylmercury in Saccharomyces cerevisiae. Mol. Pharmacol., 61, 738-741.
• Hardie, D.G. (2004): The AMP-activated protein kinase pathway--new players upstream and downstream. J. Cell. Sci., 117, 5479-5487.
• Hardie, D.G. (2005): New roles for the LKB1-->AMPK pathway. Curr. Opin. Cell Biol., 17, 167-173.

Terms in the title (9)： siRNA ,  AMPK ,  サブユニット ,  遺伝子 ,  サイレンシング ,  HEK293細胞 ,  メチル水銀 ,  毒性 ,  増強