Art

J-GLOBAL ID：201002219272592858   Reference number：10A0165625

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

二重鎖RNA依存性蛋白質キナーゼは病原体検知とストレスおよび代謝恒常性を結びつける

Author (9)： NAKAMURA Takahisa (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  FURUHASHI Masato (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  LI Ping (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  CAO Haiming (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  TUNCMAN Gurol (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  SONENBERG Nahum (Dep. of Biochemistry, McGill Univ., Montreal, Quebec H3G1Y6, CAN) ,  GORGUN Cem Z. (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  HOTAMISLIGIL Goekhan S. (Dep. of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  HOTAMISLIGIL Goekhan S. (Harvard-MIT Broad Inst., Cambridge, MA 02142, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 140  Issue： 3  Page： 338-348  Publication year： Feb. 05, 2010 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： ER stress ,  JNK MAP kinase ,  *serine-threonine kinase ,  obesity ,  experimental disease ,  enzyme activation ,  stress(physiology) ,  adipose tissue ,  liver ,  *lipid metabolism ,  fibroblast ,  cultured cell ,  phosphorylation ,  post-translational modification ,  enzyme inhibitor ,  knockout mouse ,  amino acid residue ,  protein ,  TNF alpha ,  intermolecular interaction ,  high fat diet ,  glucose tolerance test ,  carbohydrate metabolism ,  sensitivity ,  inflammation ,  intravenous administration ,  fatty acid ,  alicyclic compound ,  lactone ,  olefin compound ,  unsaturated carboxylic acid ,  polyol ,  insulin resistance ,  *insulin ,  type 2 diabetes mellitus
Semi thesaurus term： insulin resistance ,  *insulin ,  non-insulin-dependent diabetes mellitus ,  *二重鎖RNA依存性蛋白質キナーゼ ,  metabolic stress ,  Adipose Tissue, White ,  MEF cell ,  セリン残基 ,  IRS1 ,  protein-protein interaction ,  glucose metabolism ,  insulin sensitivity

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Metabolism and biotransformasion of xenobiotics  (EJ02037P) ,  Enzyme in general  (EB09010D)

Substance index (2)： Palmitic Acid ,  Thapsigargin

Terms in the title (7)： 二重鎖RNA ,  依存性 ,  蛋白質キナーゼ ,  病原体 ,  ストレス ,  代謝 ,  恒常性