Art

J-GLOBAL ID：201002220126450896   Reference number：10A0813990

A novel chiral oxazolidine organocatalyst for the synthesis of an oseltamivir intermediate using a highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine

1,2-ジヒドロピリジンの高エナンチオ選択性Diels-Alder反応を用いるオセルタミビル中間体の合成のための新しいキラルオキサゾリジン有機触媒

Author (8)： NAKANO Hiroto (Muroran Inst. Technol., Hokkaido, JPN) ,  OSONE Kenichi (Tohoku Pharmaceutical Univ., Sendai, JPN) ,  TAKESHITA Mitsuhiro (Tohoku Pharmaceutical Univ., Sendai, JPN) ,  KWON Eunsang (Tohoku Univ., sendai, JPN) ,  SEKI Chigusa (Muroran Inst. Technol., Hokkaido, JPN) ,  MATSUYAMA Haruo (Muroran Inst. Technol., Hokkaido, JPN) ,  TAKANO Nobuhiro (Muroran Inst. Technol., Hokkaido, JPN) ,  KOHARI Yoshihito (Muroran Inst. Technol., Hokkaido, JPN)
Material： Chemical Communications  (ChemComm)
Volume： 46  Issue： 26  Page： 4827-4829  Publication year： Jul. 14, 2010 
JST Material Number： D0376B  ISSN： 1359-7345  CODEN： CHCOFS  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： influenza virus ,  antiviral drug ,  catalytic reaction ,  *nitrogen heterocyclic compound ,  *Diels-Alder reaction ,  stereoselectivity ,  synthetic intermediate ,  bridged compound ,  *asymmetric catalyst ,  asymmetric synthesis ,  optical isomerism ,  *oxygen heterocyclic compound ,  catalyst preparation ,  catalytic activity ,  molecular design ,  aliphatic aldehyde ,  unsaturated aldehyde ,  vinyl compound ,  aliphatic carboxylic acid ,  aliphatic fluorine compound ,  fatty acid ,  indole alkaloid ,  carboxamide ,  phenol ether ,  polynuclear aromatic compound ,  carboxylate(ester) ,  diol ,  hydroxy acid
Semi thesaurus term： enantioselectivity ,  *oxazolidine derivative ,  *Quinuclidines ,  dihydropyridine compound ,  *organocatalyst ,  organocatalysis

JST classification (4)： Oxazoles,isoxazoles  (CF07080Y) ,  Other catalysts  (CB06123Z) ,  Addition reaction,elimination reaction  (CF02030M) ,  Other condensed derivatives of pyridine  (CF07097Y)

Substance index (12)： Oseltamivir ,  Acrolein ,  Oseltamivir phosphate ,  Trifluoroacetic Acid ,  Vincristine ,  Vinblastine ,  2β,5,5-Triphenyl-4β-phenyloxazolidine・trifluoroacetic acid ,  (4S)-2,2-Dimethyl-4-tert-butyl-5,5-diphenyloxazolidine・trifluoroacetate ,  2,2-Dimethyl-5,5-diphenyl-4β-isopropyloxazolidine・trifluoroacetic acid ,  1-(Benzyloxycarbonyl)-1,2-dihydropyridine ,  Pyridine-1(2H)-carboxylic acid tert-butyl ester ,  3-Formylacrylic acid methyl ester

Terms in the title (6)： ジヒドロピリジン ,  エナンチオ選択性 ,  Diels-Alder反応 ,  オセルタミビル ,  中間体 ,  有機触媒