Art

J-GLOBAL ID：201002222375606742   Reference number：10A0165082

Gentamicin inhibits HSP70-assisted protein folding by interfering with substrate recognition

ゲンタマイシンは基質認識を妨害することによってHSP70支援蛋白質の折畳みを阻害する

Author (13)： YAMAMOTO Soh (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN) ,  NAKANO Shunsuke (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN) ,  OWARI Kensuke (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN) ,  FUZIWARA Kazuhiko (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN) ,  OGAWA Nobuaki (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN) ,  OTAKA Michiro (Dep. of Gastroenterology, Juntendo Univ. School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, JPN) ,  TAMAKI Kumiko (Dep. of Gastroenterology, Juntendo Univ. School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, JPN) ,  WATANABE Sumio (Dep. of Gastroenterology, Juntendo Univ. School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, JPN) ,  KOMATSUDA Atsushi (Third Dep. of Internal Medicine, Akita Univ. School of Medicine, Akita 010-8543, JPN) ,  WAKUI Hideki (Third Dep. of Internal Medicine, Akita Univ. School of Medicine, Akita 010-8543, JPN) ,  SAWADA Ken-ichi (Third Dep. of Internal Medicine, Akita Univ. School of Medicine, Akita 010-8543, JPN) ,  KUBOTA Hiroshi (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN) ,  ITOH Hideaki (Dep. of Life Sci., Fac. of Engineering and Resource Sci., Akita Univ., 1-1 Tegata Gakuen Town, Akita City 010-8502, JPN)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 584  Issue： 4  Page： 645-651  Publication year： Feb. 19, 2010 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *HSP70 ,  molecular recognition ,  *chaperone protein ,  subunit ,  heat shock protein ,  concentration dependence ,  time course ,  enzyme activity ,  *folded structure ,  Molecular Weight ,  substrate recognition ,  *aminoglycoside antibiotics ,  *antibacterial drug ,  *antimicrobial drug ,  *drug
Semi thesaurus term： *gentamicin ,  Molecular Chaperones

JST classification (2)： Antibiotics in general  (GX01000E) ,  Molecular structure  (EB03020Y)

Terms in the title (8)： ゲンタマイシン ,  基質認識 ,  妨害 ,  HSP70 ,  支援 ,  蛋白質 ,  折畳み ,  阻害