Art

J-GLOBAL ID：201002223619530448   Reference number：10A1138510

Water-Stable Helical Structure of Tertiary Amides of Bicyclic β-Amino Acid Bearing 7-Azabicyclo[2.2.1]heptane. Full Control of Amide Cis-Trans Equilibrium by Bridgehead Substitution

7-アザビシクロ[2.2.1]ヘプタン構造をもつ二環β-アミノ酸第三アミドの水に安定な螺旋構造 橋頭置換によるアミドcis-trans平衡の完全制御

Author (5)： HOSOYA Masahiro (Univ. Tokyo, Tokyo, JPN) ,  OTANI Yuko (Univ. Tokyo, Tokyo, JPN) ,  KAWAHATA Masatoshi (Tokushima Bunri Univ., Kagawa, JPN) ,  YAMAGUCHI Kentaro (Tokushima Bunri Univ., Kagawa, JPN) ,  OHWADA Tomohiko (Univ. Tokyo, Tokyo, JPN)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 132  Issue： 42  Page： 14780-14789  Publication year： Oct. 27, 2010 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,  carboxylic acid ,  bridged compound ,  *amino acid ,  carboxamide ,  stability ,  helix structure ,  chemical equilibrium ,  *stereoisomer ,  steric hindrance ,  chemical synthesis ,  X-ray diffraction ,  NMR

JST classification (2)： Amino acids  (CF10070V) ,  Configuration and conformation of molecules  (BH05022J)

Substance index (12)： (1β,4S)-4-(Methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-(tert-butyloxycarbonyl)-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-carboxylic acid methyl ester ,  (1β,4S)-4-(Methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-(tert-butyloxycarbonyl)-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-carboxylic acid methyl ester ,  (1β,4S)-4-(Methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-(tert-butyloxycarbonyl)-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-carboxylic acid methyl ester ,  (1β,4S)-4-(Methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-[[(1β,4S)-4-(methoxymethyl)-7-(tert-butyloxycarbonyl)-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-yl]carbonyl]-7-azabicyclo[2.2.1]heptane-2α-carboxylic acid methyl ester ,  (1β,4S)-4-(Methoxymethyl)-7-azabicyclo[2.2.1]heptane-2α,7-dicarboxylic acid 2-methyl 7-tert-butyl ester ,  (1β,4S)-4-(Methoxymethyl)-7-acetyl-7-azabicyclo[2.2.1]heptane-2α-carboxylic acid methyl ester ,  (1β,4S)-4-(Methoxymethyl)-7-benzoyl-7-azabicyclo[2.2.1]heptane-2α-carboxylic acid methyl ester ,  (1β,4S)-4-[(4-Methoxybenzyloxy)methyl]-7-azabicyclo[2.2.1]heptane-2α,7-dicarboxylic acid 7-tert-butyl ester ,  Methyl 2-(acetylamino)acrylate ,  3-Cyclohexene-1-carboxylic acid ,  4-Methyl-7-benzoyl-7-azabicyclo[2.2.1]heptane ,  (1S,4β)-1-Methyl-5β-bromo-7-benzoyl-7-azabicyclo[2.2.1]heptane

Terms in the title (8)： ヘプタン ,  二環 ,  β-アミノ酸 ,  アミド ,  水 ,  螺旋構造 ,  置換 ,  平衡