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J-GLOBAL ID：201002228664298353   Reference number：10A0660520

The Effects of a PPARα Agonist on Myocardial Damage in Obese Diabetic Mice With Heart Failure

心不全をもつ肥満した糖尿病マウスにおける心筋障害に対するPPARαアゴニストの効果

Author (11)： CHEN Rui (Dep. of General Medicine, Himi City Hospital) ,  CHEN Rui (Dep. of Traditional Chinese Medicine, Union Hospital) ,  LIANG Fengxia (Dep. of Endocrinology, Himi City Hospital) ,  LIANG Fengxia (Hubei Coll. of Traditional Chinese Medicine) ,  MORIMOTO Shigeto (Dep. of Geriatric Medicine, Himi City Hospital) ,  LI Qian (School of Public Health, Tongji Medical Coll., Huazhong Univ. of Sci. and Technol.) ,  MORIYA Junji (Dep. of General Medicine, Himi City Hospital) ,  YAMAKAWA Jun-ichi (Dep. of General Medicine, Himi City Hospital) ,  TAKAHASHI Takashi (Dep. of General Medicine, Himi City Hospital) ,  IWAI Kunimitsu (Dep. of Geriatric Medicine, Himi City Hospital) ,  KANDA Tsugiyasu (Dep. of Community Medicine, Himi City Hospital)
Material： International Heart Journal  (Int Heart J)
Volume： 51  Issue： 3  Page： 199-206 (J-STAGE)  Publication year： 2010 
JST Material Number： Z0752A  ISSN： 1349-2365  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： hypoglycemic drug ,...
Semi thesaurus term： PPAR alpha agonist ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (1)： Wy-14643

Reference (30)：

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• 3. Tsuchida A, Yamauchi T, Takekawa S, et al. Peroxisome proliferator-activated receptor (PPAR) alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 2005; 54: 3358-70.
• 4. Ichihara S, Obata K, Yamada Y, et al. Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors. J Mol Cell Cardiol 2006; 41: 318-29.
• 5. Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005; 366: 1849-61.

Terms in the title (5)： 心不全 ,  肥満 ,  糖尿病マウス ,  心筋障害 ,  PPARαアゴニスト