Art

J-GLOBAL ID：201002233132405678   Reference number：10A0086947

Toxicologic pathological researches conducted in the Sasaki Institute in order to contribute to the risk assessment/management of chemicals (1) Findings from researches on a hepatocarcinogenic model of rats fed a choline-deficient, L-amino acid-defined diet

佐々木研究所における化学物質のリスク評価・管理に資する毒性病理学的研究 (1) コリン欠乏アミノ酸食投与ラット肝発がんモデルによる知見

Author (1)： NAKAE DAI (財団法人佐々木研究所病理部)
Material： 化学生物総合管理(Web)  (ChemoBio Integrated Management (Web))
Volume： 1  Issue： 3  Page： 331-352 (J-STAGE)  Publication year： 2005 
JST Material Number： U0068A  ISSN： 1349-9041  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *environmental management ,  safety management ,  *chemical substance ,  *risk assessment ,  risk management ,  toxicology ,  pathology ,  laboratory ,  rat ,  liver tumor ,  vitamin B deficiency
Semi thesaurus term： Choline Deficiency

JST classification (2)： Environmental problems  (SA01020V) ,  Pollutants in general  (SB05010P)

Reference (25)：

• •(1991). The LEC Rat (editors, Mori M, Yoshida N, Takeichi N, Taniguchi N). Springer-Verlag, Tokyo.
• •Ames BN, Gold LS, Willen WC (1995). The causes and prevention of cancer. Proc Natl Acad Sci USA 92: 5258-5265.
• •Canella KA, Divan BA, Gorelick PL, Donovan PJ, Sipowicz MA, Kasprzak SA, Weghorst CM, Snyderwine EG, Davis CD, Keefer LK, Kryptopoulos SA, Hecht SS, Wang M, Anderson LM, Rice JM (1996). Liver tumorigenesis by Helicobacter hepaticus. Considerations of mechanism. In Vivo 10: 285-292.
• •Denda A, Kitayama W, Kishida H, Murata N, Tsutsumi M, Tsujiuchi T, Nakae D, Konishi Y (2002a). Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet. Jpn J Cancer Res 93: 125-132.
• •Denda A, Kitayama W, Murata A, Kishida H, Sasaki Y, Kusuoka O, Tsujiuchi T, Tsutsumi M, Nakae D, Takagi H, Konishi Y (2002b). Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide. Carcinogenesis 23: 245-256.

Terms in the title (10)： 研究所 ,  化学物質 ,  リスク評価 ,  毒性病理学 ,  研究 ,  コリン欠乏アミノ酸食 ,  投与 ,  ラット ,  肝発がん ,  モデル