Art

J-GLOBAL ID：201002233132405678   Reference number：10A0086947

Toxicologic pathological researches conducted in the Sasaki Institute in order to contribute to the risk assessment/management of chemicals (1) Findings from researches on a hepatocarcinogenic model of rats fed a choline-deficient, L-amino acid-defined diet

佐々木研究所における化学物質のリスク評価・管理に資する毒性病理学的研究 (1) コリン欠乏アミノ酸食投与ラット肝発がんモデルによる知見

Author (1)： NAKAE DAI (財団法人佐々木研究所病理部)
Material： 化学生物総合管理(Web)  (ChemoBio Integrated Management (Web))
Volume： 1  Issue： 3  Page： 331-352 (J-STAGE)  Publication year： 2005 
JST Material Number： U0068A  ISSN： 1349-9041  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *environmental management ,  Safety Management ,  *chemical substance ,  *risk assessment ,  Risk Management ,  Toxicology ,  Pathology ,  laboratory ,  Rattus ,  liver tumor ,  Vitamin B Deficiency ,  Myomorpha
Semi thesaurus term： Choline Deficiency

JST classification (2)： Environmental problems  (SA01020V) ,  Pollutants in general  (SB05010P)

Reference (25)：

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• •Denda A, Kitayama W, Kishida H, Murata N, Tsutsumi M, Tsujiuchi T, Nakae D, Konishi Y (2002a). Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet. Jpn J Cancer Res 93: 125-132.
• •Denda A, Kitayama W, Murata A, Kishida H, Sasaki Y, Kusuoka O, Tsujiuchi T, Tsutsumi M, Nakae D, Takagi H, Konishi Y (2002b). Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide. Carcinogenesis 23: 245-256.

Terms in the title (10)： 研究所 ,  化学物質 ,  リスク評価 ,  毒性病理学 ,  研究 ,  コリン欠乏アミノ酸食 ,  投与 ,  ラット ,  肝発がん ,  モデル