Art

J-GLOBAL ID：201002233933099404   Reference number：10A0770523

Chemoenzymatic Synthesis of Glycan-arranged Polymeric Inhibitors against Influenza Virus Infection

糖鎖を活用したインフルエンザウイルス感染阻止剤の酵素化学合成

Author (5)： OGATA MAKOTO (静岡大学農学部) ,  MURATA TAKEOMI (静岡大学農学部) ,  BOKU RYUSHU (静岡大学創造科学技術大学院) ,  USUI TAICHI (静岡大学農学部) ,  USUI TAICHI (静岡大学創造科学技術大学院)
Material： Journal of Applied Glycoscience  (応用糖質科学)
Volume： 57  Issue： 2  Page： 137-143 (J-STAGE)  Publication year： 2010 
JST Material Number： F0614A  ISSN： 1344-7882  CODEN： JAGLFX  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： carbohydrate chain ,...
Semi thesaurus term： *inhibitor

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JST classification (3)： Gene manipulation  (EC02050B) ,  Physiology and pathogenicity of virus infection  (EG04042Y) ,  Applications of enzymes  (EB09100B)

Substance index (4)： Uridine Diphosphate N-Acetylglucosamine ,  N-Acetyllactosamine ,  5-(Trifluoroacetylamino)pentyl 4-O-β-D-galactopyranosyl-2-(acetylamino)-2-deoxy-β-D-glucopyranoside ,  5-(Trifluoroacetylamino)-1-pentanol

Reference (40)：

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• 2) Y. Suzuki, Y. Nagano, H. Kato, M. Matsumoto, K. Nerome, K. Nakajima and E. Nobusawa: Human influenza A virus hemagglutinin distinguishes sialyloligosaccharides in membrane-associated gangliosides as its receptor which mediates the adsorption and fusion processes of virus infection. J. Biol. Chem., 261, 17057-17061 (1986).
• 3) G.N. Rogers and B.L. D’Souza: Receptor binding properties of human and animal H1 influenza virus isolates. Virology, 173, 317-322 (1989).
• 4) A.S. Gambaryan, A.B. Tuzikov, V.E. Piskarev, S.S. Yamnikova, D.K. Lvov, J.S. Robertson, N.V. Bovin and M.N. Matrosovich: Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and B viruses share a common high binding affinity for 6′-sialyl(N-acetyllactosamine). Virology, 232, 345-350 (1997).
• 5) C.-L. Schengrund: “Multivalent” saccharides: development of new approaches for inhibiting the effects of glycosphingolipid-binding pathogens. Biochem. Pharmacol., 65, 699-707 (2003).

Terms in the title (6)： 糖鎖 ,  活用 ,  インフルエンザ ,  ウイルス感染 ,  阻止剤 ,  酵素化学