Art

J-GLOBAL ID：201002234202241712   Reference number：10A1145267

Inhibitory Effect of Tranilast on Endothelial Proliferation and Angiogenesis

血管内皮細胞増殖と血管新生に対するトラニラストの抑制効果

Author (13)： KIYOSAWA Tomoharu (National Defense Medical Coll., Saitama, JPN) ,  YOSHIDA Ryuichi (National Defense Medical Coll., Saitama, JPN) ,  KUBO Satoshi (National Defense Medical Coll., Saitama, JPN) ,  SUMI Yuki (National Defense Medical Coll., Saitama, JPN) ,  TAKABAYASHI Yuki (National Defense Medical Coll., Saitama, JPN) ,  ISHIKAWA Katsuya (National Defense Medical Coll., Saitama, JPN) ,  TAKIKAWA Megumi (National Defense Medical Coll., Saitama, JPN) ,  NAKAMURA Shinichiro (National Defense Medical Coll., Saitama, JPN) ,  DOMOTO Takashi (National Defense Medical Coll., Saitama, JPN) ,  SASAKI Kaoru (National Defense Medical Coll., Saitama, JPN) ,  YANAGIBAYASHI Satoshi (National Defense Medical Coll., Saitama, JPN) ,  AZUMA Ryuichi (National Defense Medical Coll., Saitama, JPN) ,  YAMAMOTO Naoto (National Defense Medical Coll., Saitama, JPN)
Material： Skin Surgery  (Journal of Japanese Society for Dermatologic Surgery)
Volume： 19  Issue： 3  Page： 127-132  Publication year： Oct. 30, 2010 
JST Material Number： L4041A  ISSN： 0918-9688  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antiallergic agent ,...
Semi thesaurus term： HUVEC ,...

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JST classification (3)： Basic dermatology  (GF01020Y) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of drugs acting on integumentum commune  (GW12010Y)

Substance index (1)： Tranilast

Reference (20)：

• Koda A, Nagai H, Watanabe S, Yanagihara Y, Sakamoto K. Inhibition of hypersensitivity reactions by a new drug, N (3′, 4′--dimethoxycinnamoyl) anthranilic acid (N-5′). J Allergy Clin Immunol 1976; 57: 396-407.
• Nishigaki T. Mast cell degranulation and its inhibition by an anti-allergic agent tranilast. An electron microscopic study. Virchows Arch B Cell Pathol Incl Mol Pathol 1988; 55: 311-22.
• Isaji M, Miyata H, Ajisawa Y, Takehana Y, Yoshimura N. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br J Pharmacol 1997; 122: 1061-6.
• Suzawa H, Kikuchi S, Arai N, Koda A. The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol 1992; 60: 91-6.
• Yamada H, Tajima 5, Nishikawa T, Murad S. Pinnell SR. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. J Biochem 1994; 116: 892-7.

Terms in the title (5)： 血管内皮細胞 ,  増殖 ,  血管新生 ,  トラニラスト ,  抑制効果