Art

J-GLOBAL ID：201002236244390990   Reference number：10A0914624

Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate

抗TNF生物学的製剤不応の活動性RA患者に対するトシリズマブの臨床評価:トシリズマブとメトトレキサートの併用

Author (17)： NAKASHIMA Yasuharu (Kyushu Univ., Fukuoka, JPN) ,  KONDO Masakazu (Kondo Clinic of Rheumatology and Orthopaedic Surgery, Fukuoka, JPN) ,  HARADA Hiroshi (Morooka Orthopedic Clinic, Fukuoka, JPN) ,  HORIUCHI Takahiko (Kyushu Univ., Fukuoka, JPN) ,  ISHINISHI Takashi (Fukuseikai Hospital, Fukuoka, JPN) ,  JOJIMA Hiroshi (Fukuoka Univ., Fukuoka, JPN) ,  KURODA Koji (Kuroda Orthopedic Hospital, Fukuoka, JPN) ,  MIYAHARA Hisaaki (National Kyushu Medical Center, Fukuoka, JPN) ,  NAGAMINE Ryuji (Sugioka Memorial Hospital, Fukuoka, JPN) ,  NAKASHIMA Hitoshi (Fukuoka Univ., Fukuoka, JPN) ,  OTSUKA Takeshi (Munakata Medical Assoc. Hospital, Fukuoka, JPN) ,  SAIKAWA Isao (Fukuoka Municipal Hospital, Fukuoka, JPN) ,  SHONO Eisuke (Shono Rheumatism Clinic, Fukuoka, JPN) ,  SUEMATSU Eiichi (Kyushu Medical Center, Fukuoka, JPN) ,  TSURU Tomomi (PS Clinic, Fukuoka, JPN) ,  WADA Ken (Wada Orthopaedic Clinic, Fukuoka, JPN) ,  IWAMOTO Yukihide (Kyushu Univ., Fukuoka, JPN)
Material： Modern Rheumatology  (Mod Rheumatol)
Volume： 20  Issue： 4  Page： 343-352  Publication year： 2010 
JST Material Number： L5142A  ISSN： 1439-7595  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *monoclonal antibody ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (2)： Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D) ,  Clinical application of anti-inflammatory drugs  (GW15020E)

Substance index (1)： Methotrexate

Reference (15)：

• WOLFE, F. The mortality of rheumatoid arthritis. Arthritis Rheum. 1994, 37, 481-494
• KANBE, K. Efficacy of arthroscopic synovectomy for the effect attenuation cases of infliximab in rheumatoid arthritis. Clin Rheumatol. 2006, 25, 877-881
• AKIRA, S. Interleukin-6 in biology and medicine. Adv Immunol. 1993, 54, 1
• TAKAGI, N. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 1998, 41, 2117-2121
• NISHIMOTO, N. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody : a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 2004, 50, 1761-1769

Terms in the title (8)： TNF ,  生物学的製剤 ,  Ra ,  患者 ,  トシリズマブ ,  臨床評価 ,  メトトレキサート ,  併用