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J-GLOBAL ID：201002237363630343   Reference number：10A0471685

High Expression of Pitx-2 in the ICAT-deficient Metanephros Leads to Developmental Arrest

ICAT欠損後腎におけるPitx-2の高発現は発達停止に至る

Author (4)： HASEGAWA Yoshimi (Dep. of Anatomy I, Fujita Health Univ. School of Medicine) ,  IIZUKA-KOGO Akiko (Dep. of Anatomy I, Fujita Health Univ. School of Medicine) ,  AKIYAMA Tetsu (Lab. of Molecular and Genetic Information, Inst. for Molecular and Cellular Biosciences, Tokyo Univ.) ,  SENDA Takao (Dep. of Anatomy I, Fujita Health Univ. School of Medicine)
Material： Acta Histochemica et Cytochemica (Web)  (Acta Histochem Cytochem (Web))
Volume： 43  Issue： 2  Page： 51-59 (J-STAGE)  Publication year： 2010 
JST Material Number： U0129A  ISSN： 1347-5800  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Proteins ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (4)： Biological function  (EB03040U) ,  Kidney  (EJ09030X) ,  Gene expression  (EC02040Q) ,  Development(=generation)and differentiation  (EJ16020W)

Reference (19)：

• 1. Clarke, J. C., Patel, S. R., Raymond, R. M., Jr., Andrew, S., Robinson, B. G., Dressler, G. R. and Brophy, P. D. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum. Mol. Genet. 15; 3420-3428.
• 2. Hasegawa, Y., Satoh, K., Iizuka-Kogo, A., Shimomura, A., Nomura, R., Akiyama, T. and Senda, T. (2007) Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis. Biochem. Biophys. Res. Commun. 362; 988-994.
• 3. Hjalt, T. A., Amendt, B. A. and Murray, J. C. (2001) PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome. J. Cell Biol. 152; 545-552.
• 4. Kioussi, C., Briata, P., Baek, S. H., Rose, D. W., Hamblet, N. S., Herman, T., Ohgi, K. A., Lin, C., Gleiberman, A., Wang, J., Brault, V., Ruiz-Lozano, P., Nguyen, H. D., Kemler, R., Glass, C. K., Wynshaw-Boris, A. and Rosenfeld, M. G. (2002) Identification of a Wnt/Dvl/beta-catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111; 673-685.
• 5. Liu, W., Selever, J., Lu, M. F. and Martin, J. F. (2003) Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development 130; 6375-6385.

Terms in the title (5)： ICAT ,  欠損 ,  後腎 ,  発現 ,  発達