Art

J-GLOBAL ID：201002240591214598   Reference number：10A0528897

Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity

有害活性化からの生理的突然変異誘発遺伝子,AIDの防止 抗体多様性を伴うゲノムの不安定性の調節

Author (5)： NAGAOKA Hitoshi (Kyoto Univ., Kyoto, JPN) ,  TRAN Thinh Huy (RIKEN, Kanagawa, JPN) ,  KOBAYASHI Maki (Kyoto Univ., Kyoto, JPN) ,  AIDA Masatoshi (Kyoto Univ., Kyoto, JPN) ,  HONJO Tasuku (Kyoto Univ., Kyoto, JPN)
Material： International Immunology  (Int Immunol)
Volume： 22  Issue： 4  Page： 227-235  Publication year： Apr. 2010 
JST Material Number： W0116A  ISSN： 0953-8178  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Cytidine Deaminase ,...
Semi thesaurus term： variation(biology) ,...

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JST classification (4)： Enzyme in general  (EB09010D) ,  Structure and chemistry of genes  (EC02020U) ,  Antigens,antibodies,complements in general  (ED04010A) ,  Gene expression  (EC02040Q)

Reference (121)：

• Honjo, T., Kinoshita, K. and Muramatsu, M. 2002. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20:165.
• Durandy, A. 2003. Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation. Eur. J. Immunol. 33:2069.
• Revy, P., Muto, T., Levy, Y. et al. 2000. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102:565.
• Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. and Honjo, T. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553.
• Yoshikawa, K., Okazaki, I. M., Eto, T. et al. 2002. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 296:2033.

Terms in the title (7)： 活性化 ,  生理 ,  突然変異誘発遺伝子 ,  AID ,  抗体多様性 ,  ゲノムの不安定性 ,  調節