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J-GLOBAL ID：201002243940863522   Reference number：10A0331487

Shikonin Directly Inhibits Nitric Oxide Synthases: Possible Targets That Affect Thoracic Aorta Relaxation Response and Nitric Oxide Release From RAW 264.7 Macrophages

シコニンは一酸化窒素シンターゼを直接阻害する:胸部大動脈弛緩反応及びRAW264.7マクロファージからの一酸化窒素放出に影響を与える可能な標的

Author (7)： YOSHIDA Lucia S. (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  KAWADA Tomie (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  IRIE Kaoru (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  YUDA Yasukatsu (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  HIMI Toshiyuki (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  IKEMOTO Fumihiko (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN) ,  TAKANO-OHMURO Hiromi (Res. Inst. of Pharmaceutical Sciences, Musashino Univ., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 112  Issue： 3  Page： 343-351 (J-STAGE)  Publication year： 2010 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： thoracic aorta ,...
Semi thesaurus term： IC50 ,...

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JST classification (4)： Aromatic monocyclic phenols and polyphenols  (CF05090V) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Enzyme in general  (EB09010D) ,  Vasculature  (EJ04030O)

Substance index (3)： Acetylcholine ,  Alkannin ,  Shikonin

Reference (32)：

• PAPAGEORGIOU, VP. The chemistry and biology of alkannin, shikonin and related naphthazarin natural products. Angew Chem Int Ed. 1999, 38, 270-300
• CHEN, X. Cellular pharmacology studies of shikonin derivatives. Phytother Res. 2002, 16, 199-209
• PAPAGEORGIOU, VP. Alkannins and shikonins : a new class of wound healing agents. Curr Med Chem. 2008, 15, 3248-3267
• TANAKA, S. A comparative study on anti-inflammatory activities of the enantiomers, skikonin and alkannin. J Nat Prod. 1986, 49, 466-469
• WANG, JP. Inhibition of hind-paw edema and cutaneous vascular plasma extravasation in mice by acetylshikonin. Eur J Pharmacol. 1995, 272, 87-95

Terms in the title (9)： シコニン ,  一酸化窒素シンターゼ ,  阻害 ,  胸部大動脈 ,  弛緩 ,  マクロファージ ,  一酸化窒素 ,  放出 ,  標的