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J-GLOBAL ID：201002251614565964   Reference number：10A0533394

Silibinin Induced Autophagic and Apoptotic Cell Death in HT1080 Cells Through a Reactive Oxygen Species Pathway

シリビニンは反応性酸素種経路を介してHT1080細胞の自食性及びアポトーシス細胞死を誘発した

Author (6)： DUAN Wenjun (China-Japan Res. Inst. of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Univ., CHN) ,  JIN Xiaoying (China-Japan Res. Inst. of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Univ., CHN) ,  LI Qisheng (China-Japan Res. Inst. of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Univ., CHN) ,  TASHIRO Shin-ichi (Dep. of Clinical and Biomedical Sciences, Showa Pharmaceutical Univ., JPN) ,  ONODERA Satoshi (Dep. of Clinical and Biomedical Sciences, Showa Pharmaceutical Univ., JPN) ,  IKEJIMA Takashi (China-Japan Res. Inst. of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Univ., CHN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 113  Issue： 1  Page： 48-56 (J-STAGE)  Publication year： 2010 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *active oxygen ,...
Semi thesaurus term： HT1080 cell ,...

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JST classification (2)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Other natural substances of biological origin  (CF10090R)

Substance index (4)： 3-Methyladenine ,  Acetylcysteine ,  Silymarin ,  Monodansyl cadaverine

Reference (38)：

• 1 Al-Anati L, Essid E, Reinehr R, Petzinger E. Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells. Mol Nutr Food Res. 2009;53:460– 466.
• 2 Jayaraj R, Deb U, Bhaskar AS, Prasad GB, Rao PV. Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice. Environ Toxicol. 2007;22:472–479.
• 3 Mokhtari MJ, Motamed N, Shokrgozar MA. Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line. Cell Biol Int. 2008;32:888– 892.
• 4 Bhatia N, Zhao J, Wolf DM, Agarwal R. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Lett. 1999;147:77–84.
• 5 Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res. 2007;143:58–65.

Terms in the title (7)： シリビニン ,  反応性酸素種 ,  経路 ,  HT1080細胞 ,  食性 ,  アポトーシス細胞死 ,  誘発