Art

J-GLOBAL ID：201002252103000183   Reference number：10A0839262

Influence of pH on Heat-Induced Aggregation and Degradation of Therapeutic Monoclonal Antibodies

治療用モノクローナル抗体の熱誘導凝集と分解に及ぼすpHの影響

Author (7)： ISHIKAWA Tomoyoshi (Bio Process Res. and Dev. Laboratories, Production Div., Kyowa Hakko Kirin Co., Ltd.) ,  ISHIKAWA Tomoyoshi (Dep. of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma Univ.) ,  ITO Takahiko (Bio Process Res. and Dev. Laboratories, Production Div., Kyowa Hakko Kirin Co., Ltd.) ,  ENDO Ryosuke (Bio Process Res. and Dev. Laboratories, Production Div., Kyowa Hakko Kirin Co., Ltd.) ,  NAKAGAWA Keiko (Bio Process Res. and Dev. Laboratories, Production Div., Kyowa Hakko Kirin Co., Ltd.) ,  SAWA Eiji (Bio Process Res. and Dev. Laboratories, Production Div., Kyowa Hakko Kirin Co., Ltd.) ,  WAKAMATSU Kaori (Dep. of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 33  Issue： 8  Page： 1413-1417 (J-STAGE)  Publication year： 2010 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *monoclonal antibody ,...
Semi thesaurus term： *IgG1 ,...

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JST classification (3)： Pharmaceutics in general  (GY01011J) ,  Antigens,antibodies,complements in general  (ED04010A) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Reference (28)：

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Terms in the title (6)： 治療 ,  モノクローナル抗体 ,  誘導 ,  凝集 ,  分解 ,  pH