Art

J-GLOBAL ID：201002257009065842   Reference number：10A1460754

A small difference in the molecular structure of angiotensin II receptor blockers induces AT₁ receptor-dependent and -independent beneficial effects

アンギオテンシンII受容体拮抗薬の分子構造の小さな違いがAT₁受容体依存的および非依存的なベネフィット効果を誘発する

Author (8)： FUJINO Masahiro (Fukuoka Univ. School of Medicine, Fukuoka, JPN) ,  MIURA Shin-ichiro (Fukuoka Univ. School of Medicine, Fukuoka, JPN) ,  MIURA Shin-ichiro (Cleveland Clinic Foundation, OH, USA) ,  KIYA Yoshihiro (Fukuoka Univ. School of Medicine, Fukuoka, JPN) ,  TOMINAGA Yukio (Dainippon Sumitomo Pharma Co. Ltd., Osaka, JPN) ,  MATSUO Yoshino (Fukuoka Univ. School of Medicine, Fukuoka, JPN) ,  KARNIK Sadashiva S (Cleveland Clinic Foundation, OH, USA) ,  SAKU Keijiro (Fukuoka Univ. School of Medicine, Fukuoka, JPN)
Material： Hypertension Research  (Hypertens Res)
Volume： 33  Issue： 10  Page： 1044-1052  Publication year： Oct. 2010 
JST Material Number： Y0303A  ISSN： 0916-9636  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *angiotensin antagonist ,...

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JST classification (1)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (2)： Irbesartan ,  Losartan

Reference (39)：

• ZAMAN, MA. Drugs targeting the renin-angiotensin-aldosterone system. Nat Rev Drug Discov. 2002, 1, 621-636
• MIURA, S. Angiotensin II receptor blocker as an inverse agonist : a current perspective. Curr Hypertens Rev. 2005, 1, 115-121
• PICCA, M. Effects of losartan and valsartan on left ventricular hypertrophy and function in essential hypertension. Adv Ther. 2004, 21, 76-86
• MATSUDA, H. Differing anti-proteinuric action of candesartan and losartan in chronic renal disease. Hypertens Res. 2003, 26, 875-880
• KOH, KK. Comparison of effects of losartan, irbesartan, and candesartan on flow-mediated brachial artery dilation and on inflammatory and thrombolytic markers in patients with systemic hypertension. Am J Cardiol. 2004, 93, 1432-1435

Terms in the title (5)： アンギオテンシンII受容体拮抗薬 ,  分子構造 ,  AT1受容体 ,  非依存 ,  誘発