Art

J-GLOBAL ID：201002263827339370   Reference number：10A0610029

Granulosa cell tumor with activated mTOR-HIF-1α-VEGF pathway

活性化mTOR-HIF-1α-VEGF経路を持つ顆粒膜細胞腫

Author (15)： MIYAZAWA Masaki (Tokai Univ. School of Medicine, Kanagawa) ,  YASUDA Masanori (Saitama Medical Univ. International Medical Center, Saitama) ,  FUJITA Mariko (Tokai Univ. School of Medicine, Kanagawa) ,  HIRABAYASHI Kenichi (Tokai Univ. School of Medicine, Kanagawa) ,  HIRASAWA Takeshi (Tokai Univ. School of Medicine, Kanagawa) ,  KAJIWARA Hiroshi (Tokai Univ. School of Medicine, Kanagawa) ,  MURAMATSU Toshinari (Tokai Univ. School of Medicine, Kanagawa) ,  MIYAZAKI Sayuri (Ebina General Hospital, Kanagawa) ,  HARASAWA Makiko (Tokai Univ. School of Medicine, Kanagawa) ,  MATSUI Naruaki (Tokai Univ. School of Medicine, Kanagawa) ,  OGANE Naoki (Kanagawa Cancer Center, Kanagawa) ,  MURAKAMI Masaru (Tokai Univ. School of Medicine, Kanagawa) ,  MIKAMI Mikio (Tokai Univ. School of Medicine, Kanagawa) ,  YANASE Toshihiko (Kyusyu Univ., Fukuoka, JPN) ,  OSAMURA R. Yoshiyuki (Tokai Univ. School of Medicine, Kanagawa)
Material： Journal of Obstetrics and Gynaecology Research  (J Obstet Gynaecol Res)
Volume： 36  Issue： 2  Page： 448-453  Publication year： Apr. 2010 
JST Material Number： W1429A  ISSN： 1341-8076  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： serine-threonine kinase ,...
Semi thesaurus term： VEGF ,...

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JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of female genitalia and fetus  (GS04000K)

Substance index (2)： Everolimus ,  Sirolimus

Reference (21)：

• HIROTA, K. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol. 2006, 59, 15-26
• JIANG, BH. Role of mTOR in anticancer drug resistance : Perspectives for improved drug treatment. Drug Resist Updat. 2008, 11, 63-76
• MABUCHI, S. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res. 2007, 67, 2408-2413
• MIYAZAWA, M. Therapeutic strategy targeting at mTOR-HIF-1α-VEGF pathway for ovarian clear cell adenocarcinoma. Pathol Int. 2009, 59, 19-27
• PECTASIDES, D. Systemic therapy in metastatic or recurrent endometrial cancer. Cancer Treat Rev. 2007, 33, 177-190

Terms in the title (6)： 活性化 ,  mTOR ,  HIF-1α ,  VEGF ,  経路 ,  顆粒膜細胞腫