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J-GLOBAL ID：201002263913501989   Reference number：10A0839077

ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating

ATMは加熱後のヒストンH2AXのリン酸化に関与する主要キナーゼである

Author (15)： TAKAHASHI Akihisa (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  MORI Eiichiro (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  SU Xiaoming (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  NAKAGAWA Yosuke (Departments of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical Univ.) ,  OKAMOTO Noritomo (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  OKAMOTO Noritomo (Departments of Otorhinolaryngology, School of Medicine, Nara Medical Univ.) ,  UEMURA Hirokazu (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  UEMURA Hirokazu (Dep. of Head and Neck Surgery, Osaka Medical Center for Cancer) ,  KONDO Natsuko (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  NODA Taichi (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  TOKI Atsushi (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  EJIMA Yosuke (Div. of Molecular Radiation Biology, Dep. of Radiation Oncology, Univ. of Texas Southwestern Medical Center) ,  CHEN David J. (Dep. of Radiological Sciences, Hiroshima Prefectural Coll. of Health Sciences) ,  OHNISHI Ken (Departments of Biology, School of Medicine, Nara Medical Univ.) ,  OHNISHI Takeo (Departments of Biology, School of Medicine, Nara Medical Univ.)
Material： Journal of Radiation Research  (J Radiat Res)
Volume： 51  Issue： 4  Page： 417-422 (J-STAGE)  Publication year： 2010 
JST Material Number： F0337A  ISSN： 0449-3060  CODEN： JRARAX  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： phosphorylation ,...
Semi thesaurus term： *ATM

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JST classification (1)： Enzyme in general  (EB09010D)

Reference (28)：

• 1. Fernandez-Capetillo O, et al (2004) H2AX: the histone guardian of the genome. DNA Repair 3: 959-967.
• 2. Bekker-Jensen S, et al (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173: 195-206.
• 3. Takahashi A and Ohnishi T (2005) Does γH2AX focus formation depend on the presence of DNA double strand breaks? Cancer Lett 229: 171-179.
• 4. Kobayashi J, et al (2008) Current topics in DNA double-strand break repair. J Radiat Res (Tokyo) 49: 93-103.
• 5. Takahashi A, et al (2004) Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res 64: 8839-8845.

Terms in the title (4)： ATM ,  ヒストンH2AX ,  リン酸化 ,  キナーゼ