Art

J-GLOBAL ID：201002270249914479   Reference number：10A0127804

Blockade of the ERK or PI3K-Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib

ERKまたはPI3K-Aktシグナル経路の阻止はゲフィチニブまたはイマチニブに抵抗性の腫瘍細胞においてヒストン脱アセチル化酵素阻害剤の細胞毒性を増強する

Author (8)： OZAKI Kei-ichi (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...) ,  KOSUGI Masaki (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...) ,  BABA Nobuyuki (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...) ,  FUJIO Kohsuke (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...) ,  SAKAMOTO Toshiaki (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...) ,  KIMURA Shinya (Div. of Hematology, Respiratory Medicine and Oncology, Dep. of Internal Medicine, Fac. of Medicine, Saga Univ. ...) ,  TANIMURA Susumu (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...) ,  KOHNO Michiaki (Lab. of Cell Regulation, Dep. of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki Univ. ...)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 391  Issue： 4  Page： 1610-1615  Publication year： Jan. 22, 2010 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： ERK ,  phosphatidylinositol 3-kinase ,  serine-threonine kinase ,  drug resistance ,  histone deacetylase ,  *cytotoxicity ,  *enzyme inhibitor ,  tyrosine kinase ,  apoptosis ,  *antitumor action
Semi thesaurus term： Akt ,  Drug Resistance ,  Protein-Tyrosine Kinase ,  Abl蛋白質

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (2)： ZD1839 ,  Imatinib

Terms in the title (12)： ERK ,  PI3K ,  Akt ,  シグナル経路 ,  阻止 ,  ゲフィチニブ ,  イマチニブ ,  抵抗性 ,  腫瘍細胞 ,  ヒストン脱アセチル化酵素阻害剤 ,  細胞毒性 ,  増強