Art

J-GLOBAL ID：201002270387315420   Reference number：10A0302349

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Skp2の不活性化は,Arf-p53非依存的な細胞老化を介した腫瘍形成の抑制を起こす

Author (18)： LIN Hui-Kuan (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  LIN Hui-Kuan (Univ. Texas M.D. Anderson Cancer Center, Texas, USA) ,  CHEN Zhenbang (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  CHEN Zhenbang (Harvard Medical School, Massachusetts, USA) ,  WANG Guocan (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  WANG Guocan (Harvard Medical School, Massachusetts, USA) ,  NARDELLA Caterina (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  NARDELLA Caterina (Harvard Medical School, Massachusetts, USA) ,  LEE Szu-Wei (Univ. Texas M.D. Anderson Cancer Center, Texas, USA) ,  CHAN Chan-Hsin (Univ. Texas M.D. Anderson Cancer Center, Texas, USA) ,  YANG Wei-Lei (Univ. Texas M.D. Anderson Cancer Center, Texas, USA) ,  WANG Jing (Univ. Texas M.D. Anderson Cancer Center, Texas, USA) ,  EGIA Ainara (Harvard Medical School, Massachusetts, USA) ,  NAKAYAMA Keiichi I. (Kyushu Univ., Fukuoka, JPN) ,  CORDON-CARDO Carlos (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  TERUYA-FELDSTEIN Julie (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  PANDOLFI Pier Paolo (Memorial Sloan-Kettering Cancer Center, New York, USA) ,  PANDOLFI Pier Paolo (Harvard Medical School, Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 464  Issue： 7287  Page： 374-379  Publication year： Mar. 18, 2010 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *cell aging ,  tumor suppressor gene ,  oncogene ,  protooncogene ,  *oncoprotein ,  p53 protein ,  GTP binding protein ,  knockout mouse ,  tumorigenesis ,  ADP ribosylation factor ,  *Skp2 ,  laboratory animal ,  Mus musculus
Semi thesaurus term： tumorigenesis ,  ARF protein ,  *Skp2 protein ,  Tumorigenesis

JST classification (2)： Cell physiology in general  (EF02010S) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (7)： Skp2 ,  不活性化 ,  ARF ,  p53 ,  非依存 ,  細胞老化 ,  腫瘍形成