Art

J-GLOBAL ID：201002278954919383   Reference number：10A0625730

Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization

ラパマイシン複合体1シグナル伝達の哺乳類標的は足場損失の影響に対抗し,Cdk4及びCdc6安定化の活性化に結びつく

Author (7)： ARAKAWA-TAKEUCHI Shiho (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...) ,  KOBAYASHI Kohei (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...) ,  PARK Jung-ha (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...) ,  URANBILEG Baasanjav (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...) ,  YAMAMOTO Hanako (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...) ,  JINNO Shigeki (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...) ,  OKAYAMA Hiroto (Dep. of Biochemistry and Molecular Biology, Graduate School and Fac. of Medicine, The Univ. of Tokyo, Tokyo 113-0033 ...)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 584  Issue： 13  Page： 2779-2785  Publication year： Jul. 02, 2010 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Extracellular Matrix ,  Cell Cycle ,  cyclin-dependent kinase ,  *Proteins ,  fibroblast ,  Rattus ,  immunosuppressant ,  tumor suppressor gene ,  Mutation ,  mutant ,  gene expression ,  *protein complex ,  enzyme inhibitor ,  GTP binding protein ,  concentration dependence ,  mRNA ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone ,  Cdc6 ,  G1 ,  *mTORC1 ,  DNA synthetic period ,  Tsc2 gene ,  *Signal Transduction ,  cyclin dependent protein kinase 2 ,  Cyclin-Dependent Kinase 4 ,  Cyclin-Dependent Kinase 6 ,  Emi1 protein ,  Ras Homolog Enriched in Brain Protein ,  *scaffold protein ,  matrix (base) ,  serine-threonine kinase ,  Myomorpha ,  molecular genetic phenomenon
Semi thesaurus term： *cellular signal transduction ,  APC/C^Cdh1 ,  CDK2 ,  Cdk4 ,  Cdk6 ,  Emi1 ,  Rheb ,  *scaffolding protein

JST classification (2)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Sirolimus

Terms in the title (11)： ラパマイシン ,  複合体 ,  シグナル伝達 ,  哺乳類 ,  標的 ,  足場 ,  損失 ,  Cdk4 ,  Cdc6 ,  安定化 ,  活性化