Art

J-GLOBAL ID：201002280061080959   Reference number：10A1004684

Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7α-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis

末期原発性胆汁性肝硬変患者の肝におけるナトリウム・タウロコール酸共輸送体ポリペプチドと胆汁酸塩輸出ポンプの持続的上方調節およびコレステロール7α-ヒドロキシラーゼの下方調節

Author (15)： TAKEYAMA Yasuaki (Fukuoka Univ., Fukuoka, JPN) ,  KANEGAE Kazuko (Fukuoka Univ., Fukuoka, JPN) ,  INOMATA Shinjiro (Fukuoka Univ., Fukuoka, JPN) ,  TAKATA Kazuhide (Fukuoka Univ., Fukuoka, JPN) ,  TANAKA Takashi (Fukuoka Univ., Fukuoka, JPN) ,  UEDA Shu-ichi (Fukuoka Univ., Fukuoka, JPN) ,  YOKOYAMA Keiji (Fukuoka Univ., Fukuoka, JPN) ,  MORIHARA Daisuke (Fukuoka Univ., Fukuoka, JPN) ,  NISHIZAWA Shinya (Fukuoka Univ., Fukuoka, JPN) ,  ANAN Akira (Fukuoka Univ., Fukuoka, JPN) ,  IRIE Makoto (Fukuoka Univ., Fukuoka, JPN) ,  IWATA Kaoru (Fukuoka Univ., Fukuoka, JPN) ,  SHAKADO Satoshi (Fukuoka Univ., Fukuoka, JPN) ,  SOHDA Tetsuro (Fukuoka Univ., Fukuoka, JPN) ,  SAKISAKA Shotaro (Fukuoka Univ., Fukuoka, JPN)
Material： Medical Molecular Morphology  (Med Mol Morphol)
Volume： 43  Issue： 3  Page： 134-138  Publication year： Sep. 2010 
JST Material Number： L1883A  ISSN： 1860-1480  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： CYP7A1 ,...

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JST classification (1)： Digestive system diseases  (GH03000W)

Reference (23)：

• TRAUNER, M. Bile salt transporters : molecular characterization, function, and regulation. Physiol Rev. 2003, 83, 633-671
• BOYER, JL. Nuclear receptor ligands : rational and effective therapy for chronic cholestatic liver disease?. Gastroenterology. 2005, 129, 735-740
• CHIANG, JY. Bile acid regulation of hepatic physiology : III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol. 2003, 284, G349-G356
• CHIANG, JY. Regulation of bile acid synthesis : pathways, nuclear receptors, and mechanisms. J Hepatol. 2004, 40, 539-551
• WAGNER, M. Transcriptional regulation of hepatobiliary transport systems in health and disease : implications for a rationale approach to the treatment of intrahepatic cholestasis. Ann Hepatol. 2005, 4, 77-99

Terms in the title (13)： 末期 ,  原発性胆汁性肝硬変 ,  患者 ,  肝 ,  ナトリウム ,  タウロコール酸 ,  共輸送体 ,  ポリペプチド ,  胆汁酸塩 ,  輸出 ,  上方調節 ,  コレステロール7α-ヒドロキシラーゼ ,  下方調節