Art

J-GLOBAL ID：201002285639718643   Reference number：10A0722808

Single Administration of α-Glucosidase Inhibitors on Endothelial Function and Incretin Secretion in Diabetic Patients With Coronary Artery Disease - Juntendo University Trial: Effects of Miglitol on Endothelial Vascular Reactivity in Type 2 Diabetic Patients With Coronary Heart Disease (J-MACH) -

冠動脈疾患を有する糖尿病患者における内皮機能及びインクレチン分泌に対するαグルコシダーゼ阻害剤の単回投与-順天堂大学試験:冠動脈性心疾患を有する2型糖尿病患者における内皮血管反応性に対するミグリトールの効果(J-MACH)-

Author (15)： HIKI Makoto (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  SHIMADA Kazunori (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  KIYANAGI Takashi (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  FUKAO Kosuke (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  HIROSE Kuniaki (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  OHSAKA Hiromichi (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  FUKUSHIMA Yoshifumi (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  KUME Atsumi (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  MATSUMORI Rie (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  SUMIYOSHI Katsuhiko (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  MIYAZAKI Tetsuro (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  OHMURA Hirotoshi (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  KURATA Takeshi (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine) ,  MIIDA Takashi (Dep. of Clinical Lab. Medicine, Juntendo Univ. School of Medicine) ,  DAIDA Hiroyuki (Dep. of Cardiovascular Medicine, Juntendo Univ. School of Medicine)
Material： Circulation Journal  (Circ J)
Volume： 74  Issue： 7  Page： 1471-1478 (J-STAGE)  Publication year： 2010 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *coronary artery disease ,...
Semi thesaurus term： insulin ,...

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JST classification (4)： Clinical application of drugs acting on carbohydrate metabolism  (GW13030B) ,  Cardiovascular system diseases  (GJ03000C) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Bioactive peptides  (EB08100U)

Substance index (3)： Glucose ,  Voglibose ,  Miglitol

Reference (33)：

• 1. Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: Meta-analysis of 37 prospective cohort studies. BMJ 2006; 332: 73-78.
• 2. Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, et al; Japan CDM group. Importance of lipid levels in elderly diabetic individuals: Baseline characteristics and 1-year survey of cardiovascular events. Circ J 2008; 72: 218-225.
• 3. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339: 229-234.
• 4. Temelkova-Kurktschiev TS, Koehler C, Henkel E, Leonhardt W, Fuecker K, Hanefeld M. Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes Care 2000; 23: 1830-1834.
• 5. Azuma K, Kawamori R, Toyofuku Y, Kitahara Y, Sato F, Shimizu T, et al. Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta. Arterioscler Thromb Vasc Biol 2006; 26: 2275-2780.

Terms in the title (13)： 冠動脈疾患 ,  糖尿病患者 ,  内皮 ,  インクレチン ,  分泌 ,  αグルコシダーゼ阻害剤 ,  単回投与 ,  試験 ,  冠動脈性心疾患 ,  2型糖尿病 ,  患者 ,  血管反応性 ,  ミグリトール