Art

J-GLOBAL ID：201002288442621248   Reference number：10A0050686

Zinc Deficiency may Accelerate Aging by Inhibiting Klotho mRNA Expression

亜鉛欠乏は,Klotho mRNAの発現を抑制することによって老化を加速し得る

Author (10)： MIYAZAKI Takashi (Saitama Medical Univ.) ,  TAKENAKA Tsuneo (Saitama Medical Univ.) ,  INOUE Tsutomu (Saitama Medical Univ.) ,  SATO Makiko (Saitama Medical Univ.) ,  EIKI Yuka (Saitama Medical Univ.) ,  NODERA Makoto (Saitama Medical Univ.) ,  HANYU Mayuko (Saitama Medical Univ.) ,  OHNO Yoichi (Saitama Medical Univ.) ,  SHIBAZAKI Satomi (Saitama Medical Univ.) ,  SUZUKI Hiromichi (Saitama Medical Univ.)
Material： Trace Nutrients Research  (微量栄養素研究)
Volume： 26  Page： 74-78  Publication year： Dec. 20, 2009 
JST Material Number： L7480A  ISSN： 1346-2334  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *zinc ,...
Semi thesaurus term： *klotho gene ,...

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JST classification (3)： Animal metabolism and nutrition in general  (EJ02031R) ,  Aging and death  (EJ16040S) ,  Gene expression  (EC02040Q)

Reference (19)：

• Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
• Aitken JM (1976) Factors affecting the distribution of zinc in the human skeleton. Calcif Tissue Res 20: 23-30.
• Haase H, Rink L (2009) The immune system and the impact of zincduring aging. Immun Ageing 6: 9.
• Vasto S, Mocchegiani E, Candore G, Listi F, Colonna-Romano G, Lio D, Malavolta M, Giacconi R, Cipriano C, Caruso C (2006) Inflammation, genes and zinc in ageing and age-related diseases. Biogerontology 7: 315-327.
• Prasad AS, Oberleas D, Wolf P, Horwitz HP (1967) Studies on zinc deficiency: changes in trace elements and enzyme activities in tissues of zinc-deficient rats. J Clin Invest 46: 549-557.

Terms in the title (5)： 亜鉛欠乏 ,  mRNA ,  発現 ,  老化 ,  加速