Art

J-GLOBAL ID：201002288573645983   Reference number：10A1456340

Carbonic anhydrase inhibitors: Gd(III) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII

炭酸脱水酵素抑制剤:腫瘍関連炭酸脱水酵素アイソザイムIXおよびXIIを標的としたDOTA-およびTETA-スルホンアミド共役のGd(III)錯体

Author (7)： RAMI Marouan (Ecole Nationale Superieure de Chimie de Montpellier, Montpellier, FRA) ,  MONTERO Jean-Louis (Ecole Nationale Superieure de Chimie de Montpellier, Montpellier, FRA) ,  DUBOIS Ludwig (Univ. Maastricht, Maastricht, NLD) ,  LAMBIN Philippe (Univ. Maastricht, Maastricht, NLD) ,  SCOZZAFAVA Andrea (Universita degli Studi di Firenze, Florence, ITA) ,  WINUM Jean-Yves (Ecole Nationale Superieure de Chimie de Montpellier, Montpellier, FRA) ,  SUPURAN Claudiu T. (Universita degli Studi di Firenze, Florence, ITA)
Material： New Journal of Chemistry  (NJC)
Volume： 34  Issue： 10  Page： 2139-2144  Publication year： Oct. 2010 
JST Material Number： H0785A  ISSN： 1144-0546  CODEN： NJCHE5  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *carbonic anhydrase inhibitor ,  *isozyme ,  *gadolinium complex ,  sulfonamide ,  genetic technique ,  screening(inspection) ,  *antitumor drug ,  tumor cell ,  cultured cell ,  HeLa cell ,  head and neck tumor ,  diagnosis ,  therapy ,  ligand effect ,  chelate compound ,  magnetic susceptibility ,  NMR imaging ,  contrast media ,  aliphatic amine ,  diamine ,  primary amine ,  secondary amine
Semi thesaurus term： HT29 Cells ,  cancer therapy ,  Drug Screening Assays, Antitumor ,  Tumor diagnosis ,  Head and Neck Cancer

JST classification (4)： Complexes of 3 group  (CE01060J) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Physicochemical characteristics of drugs  (GV01060M) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (8)： DOTA ,  Trientine ,  10-[[4-(Aminosulfonyl)benzyl]carbamoylmethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid ,  10-[[4-(Aminosulfonyl)phenethyl]carbamoylmethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid ,  10-[[4-(Aminosulfonyl)phenyl]carbamoylmethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid ,  8-[[4-(Aminosulfonyl)benzyl]carbamoylmethyl]-1,4,8,11-tetraazacyclotetradecane-1,4,11-triacetic acid ,  8-[[4-(Aminosulfonyl)phenethyl]carbamoylmethyl]-1,4,8,11-tetraazacyclotetradecane-1,4,11-triacetic acid ,  8-[[4-(Aminosulfonyl)phenyl]carbamoylmethyl]-1,4,8,11-tetraazacyclotetradecane-1,4,11-triacetic acid

Terms in the title (11)： 炭酸脱水酵素 ,  抑制剤 ,  腫瘍 ,  アイソザイム ,  標的 ,  DOTA ,  TETA ,  スルホンアミド ,  共役 ,  Gd ,  錯体